Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study.
Vitamin A supplementation (VAS) in 6-59-month-old children is recommended but its sustainability is currently questioned. In Senegal, available data suggest that VAS should be maintained, but geographic and age-related specificities need to be addressed to better implement and target VAS programming...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0246246&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184025050710016 |
|---|---|
| author | Mane Hélène Faye Marie-Madeleine A Diémé Nicole Idohou-Dossou Abdou Badiane Adama Diouf Ndeye Magatte Ndiaye Ndome Sherry A Tanumihardjo |
| author_facet | Mane Hélène Faye Marie-Madeleine A Diémé Nicole Idohou-Dossou Abdou Badiane Adama Diouf Ndeye Magatte Ndiaye Ndome Sherry A Tanumihardjo |
| author_sort | Mane Hélène Faye |
| collection | DOAJ |
| description | Vitamin A supplementation (VAS) in 6-59-month-old children is recommended but its sustainability is currently questioned. In Senegal, available data suggest that VAS should be maintained, but geographic and age-related specificities need to be addressed to better implement and target VAS programming. The objective of this comparative cross-sectional study, conducted in urban settings of Dakar, was to compare the vitamin A liver stores (VALS) assessed using the modified-relative dose response (MRDR) test between supplemented and non-supplemented 9-23 month-old children and to study their relationship with VAS. The supplemented group (n = 119) received VAS (either 100 000 UI or 200 000 UI) 2 to 6 months before evaluation while the non-supplemented group (n = 110) had not received VAS during the past 6 months. In addition to MRDR, serum retinol concentrations (SR), and biomarkers of subclinical inflammation were measured. Children's health-related data and feeding patterns were collected. Mean MRDR values (VAS: 0.030 ± 0.017, non-VAS: 0.028 ± 0.016, P = 0.389) and inflammation-adjusted SR (VAS: 1.34 ± 0.37, non-VAS: 1.3 ± 0.35, P = 0.515) of children were adequate. Low prevalence of VALS (VAS: 5.2%, non-VAS: 5.4%) and inflammation-adjusted VAD (VAS: 2.6%, non-VAS: 0.9%) were detected despite high presence of infections and inflammation. Children were mostly still being breastfed (VAS: 85.7%, non-VAS: 77.3%) and complementary feeding indicators were similar in both groups. Only breastfeeding was associated with VALS and was found to reduce by 76% at least, the odds of VAD (adjusted OR = 0.24, 95% CI: 0.07-0.8, P = 0.020). Based on MRDR values, VAS was not related to improved VALS and SR as well as VAD reduction among these children with adequate VALS. Reinforcing breastfeeding advocacy and morbidity prevention/control are essential in this setting. Scaling-back VAS in this subpopulation should be examined regarding the risk of hypervitaminosis A after an evaluation of dietary vitamin A intake sufficiency and a more quantitative assessment of VALS. |
| format | Article |
| id | doaj-art-fa4ab4c58d0e42c5b16da476c8c579a4 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fa4ab4c58d0e42c5b16da476c8c579a42025-08-20T02:17:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e024624610.1371/journal.pone.0246246Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study.Mane Hélène FayeMarie-Madeleine A DiéméNicole Idohou-DossouAbdou BadianeAdama DioufNdeye Magatte Ndiaye NdomeSherry A TanumihardjoVitamin A supplementation (VAS) in 6-59-month-old children is recommended but its sustainability is currently questioned. In Senegal, available data suggest that VAS should be maintained, but geographic and age-related specificities need to be addressed to better implement and target VAS programming. The objective of this comparative cross-sectional study, conducted in urban settings of Dakar, was to compare the vitamin A liver stores (VALS) assessed using the modified-relative dose response (MRDR) test between supplemented and non-supplemented 9-23 month-old children and to study their relationship with VAS. The supplemented group (n = 119) received VAS (either 100 000 UI or 200 000 UI) 2 to 6 months before evaluation while the non-supplemented group (n = 110) had not received VAS during the past 6 months. In addition to MRDR, serum retinol concentrations (SR), and biomarkers of subclinical inflammation were measured. Children's health-related data and feeding patterns were collected. Mean MRDR values (VAS: 0.030 ± 0.017, non-VAS: 0.028 ± 0.016, P = 0.389) and inflammation-adjusted SR (VAS: 1.34 ± 0.37, non-VAS: 1.3 ± 0.35, P = 0.515) of children were adequate. Low prevalence of VALS (VAS: 5.2%, non-VAS: 5.4%) and inflammation-adjusted VAD (VAS: 2.6%, non-VAS: 0.9%) were detected despite high presence of infections and inflammation. Children were mostly still being breastfed (VAS: 85.7%, non-VAS: 77.3%) and complementary feeding indicators were similar in both groups. Only breastfeeding was associated with VALS and was found to reduce by 76% at least, the odds of VAD (adjusted OR = 0.24, 95% CI: 0.07-0.8, P = 0.020). Based on MRDR values, VAS was not related to improved VALS and SR as well as VAD reduction among these children with adequate VALS. Reinforcing breastfeeding advocacy and morbidity prevention/control are essential in this setting. Scaling-back VAS in this subpopulation should be examined regarding the risk of hypervitaminosis A after an evaluation of dietary vitamin A intake sufficiency and a more quantitative assessment of VALS.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0246246&type=printable |
| spellingShingle | Mane Hélène Faye Marie-Madeleine A Diémé Nicole Idohou-Dossou Abdou Badiane Adama Diouf Ndeye Magatte Ndiaye Ndome Sherry A Tanumihardjo Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. PLoS ONE |
| title | Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. |
| title_full | Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. |
| title_fullStr | Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. |
| title_full_unstemmed | Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. |
| title_short | Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. |
| title_sort | adequate vitamin a liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin a supplementation in senegalese urban children 9 23 months old a comparative cross sectional study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0246246&type=printable |
| work_keys_str_mv | AT manehelenefaye adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT mariemadeleineadieme adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT nicoleidohoudossou adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT abdoubadiane adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT adamadiouf adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT ndeyemagattendiayendome adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy AT sherryatanumihardjo adequatevitaminaliverstoresestimatedbythemodifiedrelativedoseresponsetestarepositivelyassociatedwithbreastfeedingbutnotvitaminasupplementationinsenegaleseurbanchildren923monthsoldacomparativecrosssectionalstudy |