Initiation of psychotropic medication after partner bereavement: a matched cohort study.
<h4>Background</h4>Recent changes to diagnostic criteria for depression in DSM-5 remove the bereavement exclusion, allowing earlier diagnosis following bereavement. Evaluation of the potential effect of this change requires an understanding of existing psychotropic medication prescribing...
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| Format: | Article |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0077734 |
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| author | Sunil M Shah Iain M Carey Tess Harris Stephen DeWilde Christina R Victor Derek G Cook |
| author_facet | Sunil M Shah Iain M Carey Tess Harris Stephen DeWilde Christina R Victor Derek G Cook |
| author_sort | Sunil M Shah |
| collection | DOAJ |
| description | <h4>Background</h4>Recent changes to diagnostic criteria for depression in DSM-5 remove the bereavement exclusion, allowing earlier diagnosis following bereavement. Evaluation of the potential effect of this change requires an understanding of existing psychotropic medication prescribing by non-specialists after bereavement.<h4>Aims</h4>To describe initiation of psychotropic medication in the first year after partner bereavement.<h4>Methods</h4>In a UK primary care database, we identified 21,122 individuals aged 60 and over with partner bereavement and no psychotropic drug use in the previous year. Prescribing (anxiolytic/hypnotic, antidepressant, antipsychotic) after bereavement was compared to age, sex and practice matched controls.<h4>Results</h4>The risks of receiving a new psychotropic prescription within two and twelve months of bereavement were 9.5% (95% CI 9.1 to 9.9%) and 17.9% (17.3 to 18.4%) respectively; an excess risk of initiation in the first year of 12.4% compared to non-bereaved controls. Anxiolytic/hypnotic and antidepressant initiation rates were highest in the first two months. In this period, the hazard ratio for initiation of anxiolytics/hypnotics was 16.7 (95% CI 14.7 to 18.9) and for antidepressants was 5.6 (4.7 to 6.7) compared to non-bereaved controls. 13.3% of those started on anxiolytics/hypnotics within two months continued to receive this drug class at one year. The marked variation in background family practice prescribing of anxiolytics/hypnotics was the strongest determinant of their initiation in the first two months after bereavement.<h4>Conclusion</h4>Almost one in five older people received a new psychotropic drug prescription in the year after bereavement. The early increase and trend in antidepressant use after bereavement suggests some clinicians did not adhere to the bereavement exclusion, with implications for its recent removal in DSM-5. Family practice variation in use of anxiolytics/hypnotics suggests uncertainty over their role in bereavement with the potential for inappropriate long term use. |
| format | Article |
| id | doaj-art-fa485758eb874a0db4e8a3a7f1f81be3 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fa485758eb874a0db4e8a3a7f1f81be32025-08-20T02:35:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7773410.1371/journal.pone.0077734Initiation of psychotropic medication after partner bereavement: a matched cohort study.Sunil M ShahIain M CareyTess HarrisStephen DeWildeChristina R VictorDerek G Cook<h4>Background</h4>Recent changes to diagnostic criteria for depression in DSM-5 remove the bereavement exclusion, allowing earlier diagnosis following bereavement. Evaluation of the potential effect of this change requires an understanding of existing psychotropic medication prescribing by non-specialists after bereavement.<h4>Aims</h4>To describe initiation of psychotropic medication in the first year after partner bereavement.<h4>Methods</h4>In a UK primary care database, we identified 21,122 individuals aged 60 and over with partner bereavement and no psychotropic drug use in the previous year. Prescribing (anxiolytic/hypnotic, antidepressant, antipsychotic) after bereavement was compared to age, sex and practice matched controls.<h4>Results</h4>The risks of receiving a new psychotropic prescription within two and twelve months of bereavement were 9.5% (95% CI 9.1 to 9.9%) and 17.9% (17.3 to 18.4%) respectively; an excess risk of initiation in the first year of 12.4% compared to non-bereaved controls. Anxiolytic/hypnotic and antidepressant initiation rates were highest in the first two months. In this period, the hazard ratio for initiation of anxiolytics/hypnotics was 16.7 (95% CI 14.7 to 18.9) and for antidepressants was 5.6 (4.7 to 6.7) compared to non-bereaved controls. 13.3% of those started on anxiolytics/hypnotics within two months continued to receive this drug class at one year. The marked variation in background family practice prescribing of anxiolytics/hypnotics was the strongest determinant of their initiation in the first two months after bereavement.<h4>Conclusion</h4>Almost one in five older people received a new psychotropic drug prescription in the year after bereavement. The early increase and trend in antidepressant use after bereavement suggests some clinicians did not adhere to the bereavement exclusion, with implications for its recent removal in DSM-5. Family practice variation in use of anxiolytics/hypnotics suggests uncertainty over their role in bereavement with the potential for inappropriate long term use.https://doi.org/10.1371/journal.pone.0077734 |
| spellingShingle | Sunil M Shah Iain M Carey Tess Harris Stephen DeWilde Christina R Victor Derek G Cook Initiation of psychotropic medication after partner bereavement: a matched cohort study. PLoS ONE |
| title | Initiation of psychotropic medication after partner bereavement: a matched cohort study. |
| title_full | Initiation of psychotropic medication after partner bereavement: a matched cohort study. |
| title_fullStr | Initiation of psychotropic medication after partner bereavement: a matched cohort study. |
| title_full_unstemmed | Initiation of psychotropic medication after partner bereavement: a matched cohort study. |
| title_short | Initiation of psychotropic medication after partner bereavement: a matched cohort study. |
| title_sort | initiation of psychotropic medication after partner bereavement a matched cohort study |
| url | https://doi.org/10.1371/journal.pone.0077734 |
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