The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs quality of life. Treatment typically involves a patient-oriented combination of medical therapies, surgery, and lifestyle modifications. However, data on the impact of surgical treatments on quality of life re...
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2025-05-01
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| author | Lennart Ocker Nessr Abu Rached Anna Koller Carolin Frost Riina Käpynen Falk G. Bechara |
| author_facet | Lennart Ocker Nessr Abu Rached Anna Koller Carolin Frost Riina Käpynen Falk G. Bechara |
| author_sort | Lennart Ocker |
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| description | Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs quality of life. Treatment typically involves a patient-oriented combination of medical therapies, surgery, and lifestyle modifications. However, data on the impact of surgical treatments on quality of life remain limited. This prospective monocentric study aimed to evaluate the effect of wide surgical excision in patients with moderate to severe HS (Hurley stage II/III) who were naïve to systemic biologic treatments. Between March 2017 and November 2022, 82 patients (51% female; 80% Hurley II, 20% Hurley III) underwent major surgical excision. Assessments were performed before surgery and at three and six months postoperatively. The primary endpoint was the change in Dermatologic Life Quality Index (DLQI); secondary endpoints included changes in pain (NRS-11) and disease severity scores. DLQI improved from 11.7 at baseline to 8.3 at three months and 4.7 at six months (<i>p</i> < 0.001). Pain scores and the modified Hidradenitis Suppurativa Score (mHSS) also significantly decreased (<i>p</i> < 0.001). In conclusion, major surgery significantly improved quality of life and pain in HS patients, confirming its essential role in a multimodal treatment approach. Patient-reported outcome measures are crucial for assessing treatment efficacy in HS. |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-fa47667b1a97409899d89422ef4603b92025-08-20T02:33:47ZengMDPI AGLife2075-17292025-05-0115576910.3390/life15050769The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center StudyLennart Ocker0Nessr Abu Rached1Anna Koller2Carolin Frost3Riina Käpynen4Falk G. Bechara5International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyInternational Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyInternational Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyInternational Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyInternational Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyInternational Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, GermanyHidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs quality of life. Treatment typically involves a patient-oriented combination of medical therapies, surgery, and lifestyle modifications. However, data on the impact of surgical treatments on quality of life remain limited. This prospective monocentric study aimed to evaluate the effect of wide surgical excision in patients with moderate to severe HS (Hurley stage II/III) who were naïve to systemic biologic treatments. Between March 2017 and November 2022, 82 patients (51% female; 80% Hurley II, 20% Hurley III) underwent major surgical excision. Assessments were performed before surgery and at three and six months postoperatively. The primary endpoint was the change in Dermatologic Life Quality Index (DLQI); secondary endpoints included changes in pain (NRS-11) and disease severity scores. DLQI improved from 11.7 at baseline to 8.3 at three months and 4.7 at six months (<i>p</i> < 0.001). Pain scores and the modified Hidradenitis Suppurativa Score (mHSS) also significantly decreased (<i>p</i> < 0.001). In conclusion, major surgery significantly improved quality of life and pain in HS patients, confirming its essential role in a multimodal treatment approach. Patient-reported outcome measures are crucial for assessing treatment efficacy in HS.https://www.mdpi.com/2075-1729/15/5/769hidradenitis suppurativadermatologic surgeryquality of lifeinflammation |
| spellingShingle | Lennart Ocker Nessr Abu Rached Anna Koller Carolin Frost Riina Käpynen Falk G. Bechara The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study Life hidradenitis suppurativa dermatologic surgery quality of life inflammation |
| title | The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study |
| title_full | The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study |
| title_fullStr | The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study |
| title_full_unstemmed | The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study |
| title_short | The Impact of Surgery on Quality of Life in Hidradenitis Suppurativa: Results from a Prospective Single-Center Study |
| title_sort | impact of surgery on quality of life in hidradenitis suppurativa results from a prospective single center study |
| topic | hidradenitis suppurativa dermatologic surgery quality of life inflammation |
| url | https://www.mdpi.com/2075-1729/15/5/769 |
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