Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD
Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by chronic inflammation of small airways and lung parenchyma, which manifests as irreversible and progressive airflow limitation. Inhalation of toxic particles is a major risk factor for the development of COPD. Due...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | COPD |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2025.2542153 |
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| author | Ting Wang Yuanji Dong Liangjie Fang Hua Zhou |
| author_facet | Ting Wang Yuanji Dong Liangjie Fang Hua Zhou |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by chronic inflammation of small airways and lung parenchyma, which manifests as irreversible and progressive airflow limitation. Inhalation of toxic particles is a major risk factor for the development of COPD. Due to long-term exposure to cigarettes, air pollutants, or occupational pollutants, the incidence of COPD continues to be stubbornly high. Although some treatments can improve symptoms, the remodeling of small airways in COPD cannot be reversed, which still brings heavy social and economic burdens. There is evidence that airway epithelial cells are actively involved in the development of COPD. Damage, fibrotic repair, and death of airway epithelial cells lead to chronic inflammation and dysfunction of small airways. This review article summarizes the pattern of airway epithelial cell death and its role in the progression of COPD. At the same time, the corresponding mechanism is discussed in depth. |
| format | Article |
| id | doaj-art-fa442e49afa643a1b4f75b1d272a479a |
| institution | Kabale University |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-fa442e49afa643a1b4f75b1d272a479a2025-08-20T03:36:53ZengTaylor & Francis GroupCOPD1541-25551541-25632025-12-0122110.1080/15412555.2025.2542153Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPDTing Wang0Yuanji Dong1Liangjie Fang2Hua Zhou3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaChronic obstructive pulmonary disease (COPD) is a common lung disease characterized by chronic inflammation of small airways and lung parenchyma, which manifests as irreversible and progressive airflow limitation. Inhalation of toxic particles is a major risk factor for the development of COPD. Due to long-term exposure to cigarettes, air pollutants, or occupational pollutants, the incidence of COPD continues to be stubbornly high. Although some treatments can improve symptoms, the remodeling of small airways in COPD cannot be reversed, which still brings heavy social and economic burdens. There is evidence that airway epithelial cells are actively involved in the development of COPD. Damage, fibrotic repair, and death of airway epithelial cells lead to chronic inflammation and dysfunction of small airways. This review article summarizes the pattern of airway epithelial cell death and its role in the progression of COPD. At the same time, the corresponding mechanism is discussed in depth.https://www.tandfonline.com/doi/10.1080/15412555.2025.2542153Chronic obstructive pulmonary diseaseairway epithelial cellscell death |
| spellingShingle | Ting Wang Yuanji Dong Liangjie Fang Hua Zhou Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD COPD Chronic obstructive pulmonary disease airway epithelial cells cell death |
| title | Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD |
| title_full | Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD |
| title_fullStr | Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD |
| title_full_unstemmed | Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD |
| title_short | Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD |
| title_sort | patterns and underlying mechanisms of airway epithelial cell death in copd |
| topic | Chronic obstructive pulmonary disease airway epithelial cells cell death |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2025.2542153 |
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