Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI
This study aims to evaluate cerebrospinal fluid (CSF) flow dynamics within ventricles, and the subarachnoid space (SAS) using the velocity selective spin labeling (VSSL) MRI method with Fourier-transform-based velocity selective inversion preparation. The study included healthy volunteers who underw...
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Elsevier
2025-04-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925000977 |
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| author | Yihan Wu Feng Xu Dan Zhu Anna M. Li Kexin Wang Qin Qin Jiadi Xu |
| author_facet | Yihan Wu Feng Xu Dan Zhu Anna M. Li Kexin Wang Qin Qin Jiadi Xu |
| author_sort | Yihan Wu |
| collection | DOAJ |
| description | This study aims to evaluate cerebrospinal fluid (CSF) flow dynamics within ventricles, and the subarachnoid space (SAS) using the velocity selective spin labeling (VSSL) MRI method with Fourier-transform-based velocity selective inversion preparation. The study included healthy volunteers who underwent MRI scanning with specific VSSL parameters optimized for CSF flow quantification. The VSSL sequence was calibrated against phase-contrast MRI (PC-MRI) to ensure accurate flow velocity measurements. The CSF flow patterns observed in the ventricles were consistent with those obtained using 3D amplified MRI and other advanced MRI techniques, verifying the reliability of the VSSL method. The VSSL method successfully measured CSF flow in the SAS along major arteries, including the middle cerebral artery (MCA), anterior cerebral artery (ACA), and posterior cerebral artery (PCA), with an average flow velocity of 0.339±0.117cm/s. The diffusion component was well suppressed by flow-compensated gradients, enabling comprehensive mapping of the rapid CSF flow pattern in the SAS system and ventricles. The flow pattern in the SAS system closely resembles the recently discovered perivascular subarachnoid space (PVSAS) system. CSF flow around the MCA, PCA, and ACA arteries in the SAS exhibited a weak orientation dependency. CSF flow in the ventricles was also measured, with an average flow velocity of0.309±0.116cm/s, and the highest velocity observed along the superior-inferior direction. This study underscores the potential of VSSL MRI as a non-invasive tool for investigating CSF dynamics in both SAS and ventricles. |
| format | Article |
| id | doaj-art-fa40a188fbf04659b8f134528a01f1b8 |
| institution | DOAJ |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-fa40a188fbf04659b8f134528a01f1b82025-08-20T02:56:55ZengElsevierNeuroImage1095-95722025-04-0130912109510.1016/j.neuroimage.2025.121095Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRIYihan Wu0Feng Xu1Dan Zhu2Anna M. Li3Kexin Wang4Qin Qin5Jiadi Xu6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USAF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Corresponding author at: Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N. Broadway, Baltimore, MD 21205, USA.This study aims to evaluate cerebrospinal fluid (CSF) flow dynamics within ventricles, and the subarachnoid space (SAS) using the velocity selective spin labeling (VSSL) MRI method with Fourier-transform-based velocity selective inversion preparation. The study included healthy volunteers who underwent MRI scanning with specific VSSL parameters optimized for CSF flow quantification. The VSSL sequence was calibrated against phase-contrast MRI (PC-MRI) to ensure accurate flow velocity measurements. The CSF flow patterns observed in the ventricles were consistent with those obtained using 3D amplified MRI and other advanced MRI techniques, verifying the reliability of the VSSL method. The VSSL method successfully measured CSF flow in the SAS along major arteries, including the middle cerebral artery (MCA), anterior cerebral artery (ACA), and posterior cerebral artery (PCA), with an average flow velocity of 0.339±0.117cm/s. The diffusion component was well suppressed by flow-compensated gradients, enabling comprehensive mapping of the rapid CSF flow pattern in the SAS system and ventricles. The flow pattern in the SAS system closely resembles the recently discovered perivascular subarachnoid space (PVSAS) system. CSF flow around the MCA, PCA, and ACA arteries in the SAS exhibited a weak orientation dependency. CSF flow in the ventricles was also measured, with an average flow velocity of0.309±0.116cm/s, and the highest velocity observed along the superior-inferior direction. This study underscores the potential of VSSL MRI as a non-invasive tool for investigating CSF dynamics in both SAS and ventricles.http://www.sciencedirect.com/science/article/pii/S1053811925000977Cerebrospinal fluid (CSF)FlowSubarachnoid space (SAS)Velocity selective spin labeling (VSSL)Fourier-transform-based velocity selective inversion (FT-VSI)Phase-contrast MRI (PC-MRI) |
| spellingShingle | Yihan Wu Feng Xu Dan Zhu Anna M. Li Kexin Wang Qin Qin Jiadi Xu Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI NeuroImage Cerebrospinal fluid (CSF) Flow Subarachnoid space (SAS) Velocity selective spin labeling (VSSL) Fourier-transform-based velocity selective inversion (FT-VSI) Phase-contrast MRI (PC-MRI) |
| title | Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI |
| title_full | Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI |
| title_fullStr | Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI |
| title_full_unstemmed | Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI |
| title_short | Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI |
| title_sort | cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling mri |
| topic | Cerebrospinal fluid (CSF) Flow Subarachnoid space (SAS) Velocity selective spin labeling (VSSL) Fourier-transform-based velocity selective inversion (FT-VSI) Phase-contrast MRI (PC-MRI) |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000977 |
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