History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis
ABSTRACT Aim Medication adherence is critical in 5‐aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self‐discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determi...
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2025-05-01
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| Online Access: | https://doi.org/10.1002/jgh3.70181 |
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| author | Shogo Kitahata Ayaka Nakamura Yuka Kimura Mai Fukumoto Kana Matsuoka Takuya Matsuda Kazuya Murakawa Taisei Murakami Kei Onishi Hirofumi Izumoto Kozue Kanemitsu‐Okada Tomoe Kawamura Taira Kuroda Junko Matsuoka Fujimasa Tada Hideki Miyata Atsushi Hiraoka Kazuhiro Tange Yasunori Yamamoto Eiji Takeshita Yoshiou Ikeda Shinya Furukawa Eiji Tsubouchi Tomoyuki Ninomiya Yoichi Hiasa |
| author_facet | Shogo Kitahata Ayaka Nakamura Yuka Kimura Mai Fukumoto Kana Matsuoka Takuya Matsuda Kazuya Murakawa Taisei Murakami Kei Onishi Hirofumi Izumoto Kozue Kanemitsu‐Okada Tomoe Kawamura Taira Kuroda Junko Matsuoka Fujimasa Tada Hideki Miyata Atsushi Hiraoka Kazuhiro Tange Yasunori Yamamoto Eiji Takeshita Yoshiou Ikeda Shinya Furukawa Eiji Tsubouchi Tomoyuki Ninomiya Yoichi Hiasa |
| author_sort | Shogo Kitahata |
| collection | DOAJ |
| description | ABSTRACT Aim Medication adherence is critical in 5‐aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self‐discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determine the association between the history of previous medication self‐discontinuation and current adherence to 5‐aminosalicylates in patients with ulcerative colitis. Methods and Results This cross‐sectional study was conducted in Japan from 2021 to 2024. A self‐administered questionnaire was used in 228 patients with ulcerative colitis who were taking 5‐aminosalicylates. We defined adherence as consumption of ≥ 80% of the prescribed dose. Patients with a history of previous medication self‐discontinuation were defined as having discontinued medication at least once in the past by their own judgment. The current adherence rate to 5‐aminosalicylates in this study was 92.9% (212/228). The proportion of patients with a history of previous medication self‐discontinuation was 7.8% (18/228). History of previous medication self‐discontinuation (p < 0.001), younger age (p < 0.001), and once‐daily 5‐aminosalicylates regimen (p < 0.001) were inversely associated with current adherence to 5‐aminosalicylates. Conclusion History of previous medication self‐discontinuation was inversely associated with current adherence to 5‐aminosalicylates among patients with ulcerative colitis. The results of this study suggest that determining the history of previous medication self‐discontinuation may be a valuable tool in assessing current adherence to 5‐aminosalicylates, which can be cumbersome. |
| format | Article |
| id | doaj-art-fa3fc261b1c44433a7cc2755f94f7f8e |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-fa3fc261b1c44433a7cc2755f94f7f8e2025-08-20T03:48:14ZengWileyJGH Open2397-90702025-05-0195n/an/a10.1002/jgh3.70181History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative ColitisShogo Kitahata0Ayaka Nakamura1Yuka Kimura2Mai Fukumoto3Kana Matsuoka4Takuya Matsuda5Kazuya Murakawa6Taisei Murakami7Kei Onishi8Hirofumi Izumoto9Kozue Kanemitsu‐Okada10Tomoe Kawamura11Taira Kuroda12Junko Matsuoka13Fujimasa Tada14Hideki Miyata15Atsushi Hiraoka16Kazuhiro Tange17Yasunori Yamamoto18Eiji Takeshita19Yoshiou Ikeda20Shinya Furukawa21Eiji Tsubouchi22Tomoyuki Ninomiya23Yoichi Hiasa24Gastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanDepartment of Inflammatory Bowel Diseases and Therapeutics Ehime University Graduate School of Medicine Matsuyama Ehime JapanEndoscopy Center, Ehime University Graduate School of Medicine Matsuyama Ehime JapanDepartment of Inflammatory Bowel Diseases and Therapeutics Ehime University Graduate School of Medicine Matsuyama Ehime JapanEndoscopy Center, Ehime University Graduate School of Medicine Matsuyama Ehime JapanHealth Services Center, Ehime University Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanGastroenterology Center Ehime Prefectural Central Hospital Matsuyama Ehime JapanDepartment of Gastroenterology and Metabology Ehime University Graduate School of Medicine Matsuyama Ehime JapanABSTRACT Aim Medication adherence is critical in 5‐aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self‐discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determine the association between the history of previous medication self‐discontinuation and current adherence to 5‐aminosalicylates in patients with ulcerative colitis. Methods and Results This cross‐sectional study was conducted in Japan from 2021 to 2024. A self‐administered questionnaire was used in 228 patients with ulcerative colitis who were taking 5‐aminosalicylates. We defined adherence as consumption of ≥ 80% of the prescribed dose. Patients with a history of previous medication self‐discontinuation were defined as having discontinued medication at least once in the past by their own judgment. The current adherence rate to 5‐aminosalicylates in this study was 92.9% (212/228). The proportion of patients with a history of previous medication self‐discontinuation was 7.8% (18/228). History of previous medication self‐discontinuation (p < 0.001), younger age (p < 0.001), and once‐daily 5‐aminosalicylates regimen (p < 0.001) were inversely associated with current adherence to 5‐aminosalicylates. Conclusion History of previous medication self‐discontinuation was inversely associated with current adherence to 5‐aminosalicylates among patients with ulcerative colitis. The results of this study suggest that determining the history of previous medication self‐discontinuation may be a valuable tool in assessing current adherence to 5‐aminosalicylates, which can be cumbersome.https://doi.org/10.1002/jgh3.701815‐aminosalicylatesadherenceulcerative colitis |
| spellingShingle | Shogo Kitahata Ayaka Nakamura Yuka Kimura Mai Fukumoto Kana Matsuoka Takuya Matsuda Kazuya Murakawa Taisei Murakami Kei Onishi Hirofumi Izumoto Kozue Kanemitsu‐Okada Tomoe Kawamura Taira Kuroda Junko Matsuoka Fujimasa Tada Hideki Miyata Atsushi Hiraoka Kazuhiro Tange Yasunori Yamamoto Eiji Takeshita Yoshiou Ikeda Shinya Furukawa Eiji Tsubouchi Tomoyuki Ninomiya Yoichi Hiasa History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis JGH Open 5‐aminosalicylates adherence ulcerative colitis |
| title | History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis |
| title_full | History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis |
| title_fullStr | History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis |
| title_full_unstemmed | History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis |
| title_short | History of Previous Medication Self‐Discontinuation Predicts the Current Adherence to 5‐Aminosalicylates in Patients With Ulcerative Colitis |
| title_sort | history of previous medication self discontinuation predicts the current adherence to 5 aminosalicylates in patients with ulcerative colitis |
| topic | 5‐aminosalicylates adherence ulcerative colitis |
| url | https://doi.org/10.1002/jgh3.70181 |
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