Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles
Introduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk of human infection. Prolonged dosage forms of ivermectin are effective against them. The first step in the creation of...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2022-05-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/1220 |
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| author | O. I. Rybchenko V. V. Suslov S. A. Kedik Yu. M. Domnina A. I. Mogaibo |
| author_facet | O. I. Rybchenko V. V. Suslov S. A. Kedik Yu. M. Domnina A. I. Mogaibo |
| author_sort | O. I. Rybchenko |
| collection | DOAJ |
| description | Introduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk of human infection. Prolonged dosage forms of ivermectin are effective against them. The first step in the creation of such a drug was the preparation and study of polymeric microparticles of polycaprolactone with encapsulated ivermectin.Aim. Obtaining polymeric microparticles of polycaprolactone with encapsulated ivermectin using a continuous flow-through unit.Materials and methods. The object of the study was microparticles of polycaprolactone with encapsulated ivermectin obtained on a continuous flow-through unit. Determination of the average particle size and size distribution was carried out by the method of laser diffraction. Microscopy was used to visually assess the shape and size of the microparticles. UV – spectrophotometry was use to quantitative determination of ivermectin.Results and discussion. Polymeric microparticles of polycaprolactone with encapsulated ivermectin was obtained and had an average size of 126.63 ± 42.67 μm and contained 32,73–62,00 % of ivermectin. Suspensions prepared from the obtained microparticles were passed through a 20G injection needle without noticeable resistance, which indicates the possibility of their use as the basis of an injectable preparation.Conclusion. Obtained results confirm the possibility of using flow-through dispersion using a device developed by us for obtaining polycaprolactone microparticles with encapsulated ivermectin, which are suitable for injection. Thus, the results obtained make it possible to continue studies of microparticles and create a drug based on them. |
| format | Article |
| id | doaj-art-fa3ef44b7ce246b087dec8554a79db18 |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-fa3ef44b7ce246b087dec8554a79db182025-08-20T03:39:40ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492022-05-01112798610.33380/2305-2066-2022-11-2-79-86958Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone MicroparticlesO. I. Rybchenko0V. V. Suslov1S. A. Kedik2Yu. M. Domnina3A. I. Mogaibo4Federal State Budget Educational Institution of Higher Education "MIREA – Russian Technological University"Federal State Budget Educational Institution of Higher Education "MIREA – Russian Technological University"Federal State Budget Educational Institution of Higher Education "MIREA – Russian Technological University"Federal State Budget Educational Institution of Higher Education "MIREA – Russian Technological University"Federal State Budget Educational Institution of Higher Education "MIREA – Russian Technological University"; JSC Institute of Pharmaceutical TechnologiesIntroduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk of human infection. Prolonged dosage forms of ivermectin are effective against them. The first step in the creation of such a drug was the preparation and study of polymeric microparticles of polycaprolactone with encapsulated ivermectin.Aim. Obtaining polymeric microparticles of polycaprolactone with encapsulated ivermectin using a continuous flow-through unit.Materials and methods. The object of the study was microparticles of polycaprolactone with encapsulated ivermectin obtained on a continuous flow-through unit. Determination of the average particle size and size distribution was carried out by the method of laser diffraction. Microscopy was used to visually assess the shape and size of the microparticles. UV – spectrophotometry was use to quantitative determination of ivermectin.Results and discussion. Polymeric microparticles of polycaprolactone with encapsulated ivermectin was obtained and had an average size of 126.63 ± 42.67 μm and contained 32,73–62,00 % of ivermectin. Suspensions prepared from the obtained microparticles were passed through a 20G injection needle without noticeable resistance, which indicates the possibility of their use as the basis of an injectable preparation.Conclusion. Obtained results confirm the possibility of using flow-through dispersion using a device developed by us for obtaining polycaprolactone microparticles with encapsulated ivermectin, which are suitable for injection. Thus, the results obtained make it possible to continue studies of microparticles and create a drug based on them.https://www.pharmjournal.ru/jour/article/view/1220ivermectinpolycaprolactonemicroparticlesmicrofluidic deviceprolonged-release druginjectable drug |
| spellingShingle | O. I. Rybchenko V. V. Suslov S. A. Kedik Yu. M. Domnina A. I. Mogaibo Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles Разработка и регистрация лекарственных средств ivermectin polycaprolactone microparticles microfluidic device prolonged-release drug injectable drug |
| title | Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles |
| title_full | Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles |
| title_fullStr | Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles |
| title_full_unstemmed | Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles |
| title_short | Flow Dispersion for Obtaining Ivermectin Encapsulated in Polycaprolactone Microparticles |
| title_sort | flow dispersion for obtaining ivermectin encapsulated in polycaprolactone microparticles |
| topic | ivermectin polycaprolactone microparticles microfluidic device prolonged-release drug injectable drug |
| url | https://www.pharmjournal.ru/jour/article/view/1220 |
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