PPAR Action in Human Placental Development and Pregnancy and Its Complications
During pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic system...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/527048 |
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| author | Fritz Wieser Leslie Waite Christophe Depoix Robert N. Taylor |
| author_facet | Fritz Wieser Leslie Waite Christophe Depoix Robert N. Taylor |
| author_sort | Fritz Wieser |
| collection | DOAJ |
| description | During pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic systems that appears to have evolved to sustain this metabolic regulation is mediated by peroxisome proliferator-activated receptors (PPARs). In clinical pregnancy-specific disorders, including preeclampsia, gestational diabetes, and intrauterine growth restriction, aberrant regulation of components of the PPAR system parallels dysregulation of metabolism, inflammation and angiogenesis. This review summarizes current knowledge on the role of PPARs in regulating human trophoblast invasion, early placental development, and also in the physiology of clinical pregnancy and its complications. As increasingly indicated in the literature, pregnancy disorders, such as preeclampsia and gestational diabetes, represent potential targets for treatment with PPAR ligands. With the advent of more specific PPAR agonists that exhibit efficacy in ameliorating metabolic, inflammatory, and angiogenic disturbances, further studies of their application in pregnancy-related diseases are warranted. |
| format | Article |
| id | doaj-art-fa3eb7231ebc45389243d82cc0d61c35 |
| institution | DOAJ |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-fa3eb7231ebc45389243d82cc0d61c352025-08-20T03:20:03ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/527048527048PPAR Action in Human Placental Development and Pregnancy and Its ComplicationsFritz Wieser0Leslie Waite1Christophe Depoix2Robert N. Taylor3Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USADuring pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic systems that appears to have evolved to sustain this metabolic regulation is mediated by peroxisome proliferator-activated receptors (PPARs). In clinical pregnancy-specific disorders, including preeclampsia, gestational diabetes, and intrauterine growth restriction, aberrant regulation of components of the PPAR system parallels dysregulation of metabolism, inflammation and angiogenesis. This review summarizes current knowledge on the role of PPARs in regulating human trophoblast invasion, early placental development, and also in the physiology of clinical pregnancy and its complications. As increasingly indicated in the literature, pregnancy disorders, such as preeclampsia and gestational diabetes, represent potential targets for treatment with PPAR ligands. With the advent of more specific PPAR agonists that exhibit efficacy in ameliorating metabolic, inflammatory, and angiogenic disturbances, further studies of their application in pregnancy-related diseases are warranted.http://dx.doi.org/10.1155/2008/527048 |
| spellingShingle | Fritz Wieser Leslie Waite Christophe Depoix Robert N. Taylor PPAR Action in Human Placental Development and Pregnancy and Its Complications PPAR Research |
| title | PPAR Action in Human Placental Development and Pregnancy and Its Complications |
| title_full | PPAR Action in Human Placental Development and Pregnancy and Its Complications |
| title_fullStr | PPAR Action in Human Placental Development and Pregnancy and Its Complications |
| title_full_unstemmed | PPAR Action in Human Placental Development and Pregnancy and Its Complications |
| title_short | PPAR Action in Human Placental Development and Pregnancy and Its Complications |
| title_sort | ppar action in human placental development and pregnancy and its complications |
| url | http://dx.doi.org/10.1155/2008/527048 |
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