5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target

5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target

Abstract Metachronous liver metastases (MLM) are characterised by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronous liver metastasis in colorectal cancer. Based on 5h...

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Main Authors: Nuo Xu, Zhaoya Gao, Deyan Wu, Hangyu Chen, Zijian Zhang, Lei Zhang, Yuchen Wang, Xuyang Lu, Xu Yao, Xuelan Liu, Yi‐You Huang, Meiying Qiu, Sen Wang, Jinqiang Liang, Can Mao, Feng Zhang, Huimin Xu, Yujiao Wang, Xian Li, Zhexin Chen, Dandan Huang, Jingyi Shi, Wensheng Huang, Fuming Lei, Zeruo Yang, Long Chen, Chuan He, Haichuan Zhu, Hai‐Bin Luo, Jin Gu, Jian Lin
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
5hmC‐Seal
Colorectal cancer
Metachronous liver metastases
PDE4D
Online Access:https://doi.org/10.1002/ctm2.70189
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