From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents
Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural changes that improve their...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/72 |
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| author | Hesham M. Hassan Roket Hassan Ranya Mohammed Elmagzoub Ahmed Al-Emam Konstantinos Kossenas Ahmed S. Abdel-Samea Hazim O. Khalifa Suleyman Akocak Stefan Bräse Hamada Hashem |
| author_facet | Hesham M. Hassan Roket Hassan Ranya Mohammed Elmagzoub Ahmed Al-Emam Konstantinos Kossenas Ahmed S. Abdel-Samea Hazim O. Khalifa Suleyman Akocak Stefan Bräse Hamada Hashem |
| author_sort | Hesham M. Hassan |
| collection | DOAJ |
| description | Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural changes that improve their therapeutic effectiveness by modifying the basic group at position 7, the carboxylic acid group at position 3, or both. It further investigates the mechanisms by which these derivatives fight cancer, such as inducing apoptosis, arresting the cell cycle, inhibiting topoisomerase I and II, preventing tubulin polymerization, suppressing interleukin 6, blocking thymidine phosphorylase, inhibiting multidrug resistance proteins, and hindering angiogenesis. Additionally, it outlines their future directions, such as enhancing their efficacy, selectivity, and investigating potential synergy with other chemotherapeutic agents, offering a promising avenue for developing new therapies for cancer. |
| format | Article |
| id | doaj-art-fa30a4c09820485c87ce1d946a71d405 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-fa30a4c09820485c87ce1d946a71d4052025-01-24T13:45:17ZengMDPI AGPharmaceuticals1424-82472025-01-011817210.3390/ph18010072From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer AgentsHesham M. Hassan0Roket Hassan1Ranya Mohammed Elmagzoub2Ahmed Al-Emam3Konstantinos Kossenas4Ahmed S. Abdel-Samea5Hazim O. Khalifa6Suleyman Akocak7Stefan Bräse8Hamada Hashem9Department of Pathology, College of Medicine, King Khalid University, Asir 61421, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, EgyptDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar 73311, Saudi ArabiaDepartment of Pathology, College of Medicine, King Khalid University, Asir 61421, Saudi ArabiaDepartment of Basic and Clinical Sciences, University of Nicosia Medical School, P.O. Box 24005, 21 Ilia Papakyriakou, 2414 Engomi, CY-1700 Nicosia, CyprusPharmacology & Toxicology Department, Faculty of Pharmacy, Deraya University, New Minia 61768, EgyptDepartment of Pharmacology, Faculty of Veterinary Medicinea, Kafrelsheikh University, Kafrelsheikh 33516, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman 02040, TürkiyeInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, GermanyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, EgyptCiprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural changes that improve their therapeutic effectiveness by modifying the basic group at position 7, the carboxylic acid group at position 3, or both. It further investigates the mechanisms by which these derivatives fight cancer, such as inducing apoptosis, arresting the cell cycle, inhibiting topoisomerase I and II, preventing tubulin polymerization, suppressing interleukin 6, blocking thymidine phosphorylase, inhibiting multidrug resistance proteins, and hindering angiogenesis. Additionally, it outlines their future directions, such as enhancing their efficacy, selectivity, and investigating potential synergy with other chemotherapeutic agents, offering a promising avenue for developing new therapies for cancer.https://www.mdpi.com/1424-8247/18/1/72ciprofloxacinanticancertopoisomerases I and II inhibitorsapoptosis inducerscell cycle arrest |
| spellingShingle | Hesham M. Hassan Roket Hassan Ranya Mohammed Elmagzoub Ahmed Al-Emam Konstantinos Kossenas Ahmed S. Abdel-Samea Hazim O. Khalifa Suleyman Akocak Stefan Bräse Hamada Hashem From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents Pharmaceuticals ciprofloxacin anticancer topoisomerases I and II inhibitors apoptosis inducers cell cycle arrest |
| title | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents |
| title_full | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents |
| title_fullStr | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents |
| title_full_unstemmed | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents |
| title_short | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents |
| title_sort | from infection to tumor exploring the therapeutic potential of ciprofloxacin derivatives as anticancer agents |
| topic | ciprofloxacin anticancer topoisomerases I and II inhibitors apoptosis inducers cell cycle arrest |
| url | https://www.mdpi.com/1424-8247/18/1/72 |
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