Treatment of parry-romberg syndrome and linear scleroderma en coup de sabre, with application of poly-L-lactic acid (PLLA): assessment of clinical response and high-resolution ultrasonography

INTRODUCTION: Parry-Romberg syndrome and linear scleroderma en coup de sabre are disorders within the scleroderma spectrum, a disease that presents therapeutic challenges. OBJECTIVES: We treated three patients with this condition using poly-L-lactic acid (PLLA) with the aim of alleviatin...

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Main Authors: Renato Roberto Liberato Rostey, Cristiane Ferreira Rallo de Almeida, Danilo Olavarria D'Aquino, Caio Leal Carvalho
Format: Article
Language:English
Published: Sociedade Brasileira de Dermatologia (SBD) 2025-04-01
Series:Surgical & Cosmetic Dermatology
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Online Access:http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250361.pdf
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Summary:INTRODUCTION: Parry-Romberg syndrome and linear scleroderma en coup de sabre are disorders within the scleroderma spectrum, a disease that presents therapeutic challenges. OBJECTIVES: We treated three patients with this condition using poly-L-lactic acid (PLLA) with the aim of alleviating facial asymmetries and evaluated the real improvement of scleroderma lesions with high-resolution ultrasound. METHODS: The patients underwent two to four sessions of biostimulation with PLLA over a 12-month period. RESULTS: The results were promising, demonstrating favorable cosmetic outcomes with increased thickness of the dermis and hypodermis as evidenced by high-resolution ultrasound. CONCLUSIONS: Biostimulation with PLLA is a safe and effective treatment option for these patients when administered by trained professionals.
ISSN:1984-8773