Microalgae as expression systems for recombinant protein production
In the field of biotechnology, recombinant proteins have revolutionized many industries, including pharmaceuticals, agriculture, and bioenergy. By producing high-value proteins in heterologous hosts, cell factories may offer a more efficient, cost-effective, scalable, and environmentally friendly...
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| Format: | Article |
| Language: | English |
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Instituto Tecnológico de Costa Rica
2024-11-01
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| Series: | Tecnología en Marcha |
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| Online Access: | https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/7608 |
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| author | Luis Muñoz-Solórzano Kate Willis-Ureña Sebastián Valverde-Rojas Montserrat Jarquín-Cordero Luis Barboza-Fallas |
| author_facet | Luis Muñoz-Solórzano Kate Willis-Ureña Sebastián Valverde-Rojas Montserrat Jarquín-Cordero Luis Barboza-Fallas |
| author_sort | Luis Muñoz-Solórzano |
| collection | DOAJ |
| description | In the field of biotechnology, recombinant proteins have revolutionized many industries,
including pharmaceuticals, agriculture, and bioenergy. By producing high-value proteins
in heterologous hosts, cell factories may offer a more efficient, cost-effective, scalable, and
environmentally friendly solution to traditional protein production and extraction methods,
which can be highly laborious and resource intensive. Microalgae have emerged as attractive
hosts due to their Generally Recognized as Safe (GRAS) status, versatile metabolism, genetic
diversity between species, ease of cultivation and scale-up, and general cost-effectiveness.
For genetic engineering, their capability for complex protein synthesis and post-translational
modifications and ease of transformation in comparison with chasses outside of their category
make microalgae an advantageous solution on many fronts. Microalgae can be transformed to
enable efficient protein expression, most commonly in the nucleus and the chloroplast, each
with their specific advantages and limitations. The present literature review compiles some
of the techniques, features, and latest advances related to recombinant protein production
in microalgae, exploring different genetic transformation techniques and their limitations.
Recombinant protein production is only one of the many processes that can become more
sustainable and efficient by using microalgae as a platform. |
| format | Article |
| id | doaj-art-fa2a3d8f02994c088e32beceafdc82d0 |
| institution | OA Journals |
| issn | 0379-3982 2215-3241 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Instituto Tecnológico de Costa Rica |
| record_format | Article |
| series | Tecnología en Marcha |
| spelling | doaj-art-fa2a3d8f02994c088e32beceafdc82d02025-08-20T02:04:34ZengInstituto Tecnológico de Costa RicaTecnología en Marcha0379-39822215-32412024-11-01ág. 3247.10.18845/tm.v37i9.76086882Microalgae as expression systems for recombinant protein productionLuis Muñoz-Solórzano0https://orcid.org/0000-0002-6960-377XKate Willis-Ureña1https://orcid.org/0000-0002-6971-2204Sebastián Valverde-Rojas2https://orcid.org/0009-0002-1254-8244Montserrat Jarquín-Cordero3https://orcid.org/0000-0001-7926-7290Luis Barboza-Fallas4https://orcid.org/0000-0003-1669-3764Instituto tecnológico de Costa RicaInstituto tecnológico de Costa RicaInstituto tecnológico de Costa RicaInstituto tecnológico de Costa RicaInstituto tecnológico de Costa RicaIn the field of biotechnology, recombinant proteins have revolutionized many industries, including pharmaceuticals, agriculture, and bioenergy. By producing high-value proteins in heterologous hosts, cell factories may offer a more efficient, cost-effective, scalable, and environmentally friendly solution to traditional protein production and extraction methods, which can be highly laborious and resource intensive. Microalgae have emerged as attractive hosts due to their Generally Recognized as Safe (GRAS) status, versatile metabolism, genetic diversity between species, ease of cultivation and scale-up, and general cost-effectiveness. For genetic engineering, their capability for complex protein synthesis and post-translational modifications and ease of transformation in comparison with chasses outside of their category make microalgae an advantageous solution on many fronts. Microalgae can be transformed to enable efficient protein expression, most commonly in the nucleus and the chloroplast, each with their specific advantages and limitations. The present literature review compiles some of the techniques, features, and latest advances related to recombinant protein production in microalgae, exploring different genetic transformation techniques and their limitations. Recombinant protein production is only one of the many processes that can become more sustainable and efficient by using microalgae as a platform.https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/7608genetictransformationgenetic engineeringrecombinant proteinmicroalgae |
| spellingShingle | Luis Muñoz-Solórzano Kate Willis-Ureña Sebastián Valverde-Rojas Montserrat Jarquín-Cordero Luis Barboza-Fallas Microalgae as expression systems for recombinant protein production Tecnología en Marcha genetic transformation genetic engineering recombinant protein microalgae |
| title | Microalgae as expression systems for recombinant protein production |
| title_full | Microalgae as expression systems for recombinant protein production |
| title_fullStr | Microalgae as expression systems for recombinant protein production |
| title_full_unstemmed | Microalgae as expression systems for recombinant protein production |
| title_short | Microalgae as expression systems for recombinant protein production |
| title_sort | microalgae as expression systems for recombinant protein production |
| topic | genetic transformation genetic engineering recombinant protein microalgae |
| url | https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/7608 |
| work_keys_str_mv | AT luismunozsolorzano microalgaeasexpressionsystemsforrecombinantproteinproduction AT katewillisurena microalgaeasexpressionsystemsforrecombinantproteinproduction AT sebastianvalverderojas microalgaeasexpressionsystemsforrecombinantproteinproduction AT montserratjarquincordero microalgaeasexpressionsystemsforrecombinantproteinproduction AT luisbarbozafallas microalgaeasexpressionsystemsforrecombinantproteinproduction |