Pediatric bacterial meningitis in southern China: analysis of 838 cases
ObjectiveThis work aims to study the clinical features and risk factors of children with bacterial meningitis (BM) in southern China.MethodsClinical data of children with BM between 2012 and 2018 from one national center were analyzed retrospectively.ResultsA total of 838 patients (male/female = 1.8...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1481716/full |
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| author | Lianfeng Chen Wen-Lin Wu Yuanyuan Gao Xiaojing Li Sida Yang Huici Liang Kelu Zheng Yani Zhang Haixia Zhu Yang Tian Bingwei Peng Haisheng Lin Xiuying Wang Shuyao Ning Yinyan Gan Chi Hou Yinting Liao Huiling Sheng Wen-Xiong Chen Wen-Xiong Chen |
| author_facet | Lianfeng Chen Wen-Lin Wu Yuanyuan Gao Xiaojing Li Sida Yang Huici Liang Kelu Zheng Yani Zhang Haixia Zhu Yang Tian Bingwei Peng Haisheng Lin Xiuying Wang Shuyao Ning Yinyan Gan Chi Hou Yinting Liao Huiling Sheng Wen-Xiong Chen Wen-Xiong Chen |
| author_sort | Lianfeng Chen |
| collection | DOAJ |
| description | ObjectiveThis work aims to study the clinical features and risk factors of children with bacterial meningitis (BM) in southern China.MethodsClinical data of children with BM between 2012 and 2018 from one national center were analyzed retrospectively.ResultsA total of 838 patients (male/female = 1.8:1) were enrolled, with 90.6% under 1 year old. Common symptoms included fever, seizure, lethargy, vomiting, anorexia, poor feeding, and irritability. Most patients initially exhibited typical cerebrospinal fluid (CSF) changes of BM, including elevated white blood cell count, increased protein levels, and decreased glucose concentration. Some initially atypical cases showed typical changes after about 1 week. Furthermore, 38.7% of the patients had positive bacterial cultures of blood or CSF, with Streptococcus agalactiae, Escherichia coli, and Streptococcus pneumoniae commonly seen. Moreover, 92.0% of the patients were graded five Glasgow outcome scale (GOS) points at discharge. Differences in symptoms, pathogens, CSF results, brain MRI, and GOS points were observed across age groups (neonate [29 days, 12 months) and aged ≥12 months). Fatality rate was 1.9%, and 10.7% of survivors had neurological sequelae. Recurrent BM was rare (1.6%) but notable in patients with CSF fistula or immunodeficiency. Risk factors for intensive care unit admission, brain parenchymal involvement, subdural effusion, and hearing impairment were identified.ConclusionMost pediatric BM patients in southern China were under 1 year old, with more distribution in male patients and some age-related differences in clinical features and outcomes. Recurrent BM is rare but more likely in patients with conditions such as CSF fistula or immunodeficiency. Most patients have favorable outcomes, with a low fatality rate and around 10% of the survivors experiencing neurological sequelae. Several clinical risk factors were identified. |
| format | Article |
| id | doaj-art-fa28af87f304458cbf25a55ec203f8dd |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-fa28af87f304458cbf25a55ec203f8dd2025-02-05T07:32:23ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.14817161481716Pediatric bacterial meningitis in southern China: analysis of 838 casesLianfeng Chen0Wen-Lin Wu1Yuanyuan Gao2Xiaojing Li3Sida Yang4Huici Liang5Kelu Zheng6Yani Zhang7Haixia Zhu8Yang Tian9Bingwei Peng10Haisheng Lin11Xiuying Wang12Shuyao Ning13Yinyan Gan14Chi Hou15Yinting Liao16Huiling Sheng17Wen-Xiong Chen18Wen-Xiong Chen19Department of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Behavioral Development, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaObjectiveThis work aims to study the clinical features and risk factors of children with bacterial meningitis (BM) in southern China.MethodsClinical data of children with BM between 2012 and 2018 from one national center were analyzed retrospectively.ResultsA total of 838 patients (male/female = 1.8:1) were enrolled, with 90.6% under 1 year old. Common symptoms included fever, seizure, lethargy, vomiting, anorexia, poor feeding, and irritability. Most patients initially exhibited typical cerebrospinal fluid (CSF) changes of BM, including elevated white blood cell count, increased protein levels, and decreased glucose concentration. Some initially atypical cases showed typical changes after about 1 week. Furthermore, 38.7% of the patients had positive bacterial cultures of blood or CSF, with Streptococcus agalactiae, Escherichia coli, and Streptococcus pneumoniae commonly seen. Moreover, 92.0% of the patients were graded five Glasgow outcome scale (GOS) points at discharge. Differences in symptoms, pathogens, CSF results, brain MRI, and GOS points were observed across age groups (neonate [29 days, 12 months) and aged ≥12 months). Fatality rate was 1.9%, and 10.7% of survivors had neurological sequelae. Recurrent BM was rare (1.6%) but notable in patients with CSF fistula or immunodeficiency. Risk factors for intensive care unit admission, brain parenchymal involvement, subdural effusion, and hearing impairment were identified.ConclusionMost pediatric BM patients in southern China were under 1 year old, with more distribution in male patients and some age-related differences in clinical features and outcomes. Recurrent BM is rare but more likely in patients with conditions such as CSF fistula or immunodeficiency. Most patients have favorable outcomes, with a low fatality rate and around 10% of the survivors experiencing neurological sequelae. Several clinical risk factors were identified.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1481716/fullbacterial meningitisclinical featureschildrenprognosisrisk factors |
| spellingShingle | Lianfeng Chen Wen-Lin Wu Yuanyuan Gao Xiaojing Li Sida Yang Huici Liang Kelu Zheng Yani Zhang Haixia Zhu Yang Tian Bingwei Peng Haisheng Lin Xiuying Wang Shuyao Ning Yinyan Gan Chi Hou Yinting Liao Huiling Sheng Wen-Xiong Chen Wen-Xiong Chen Pediatric bacterial meningitis in southern China: analysis of 838 cases Frontiers in Cellular and Infection Microbiology bacterial meningitis clinical features children prognosis risk factors |
| title | Pediatric bacterial meningitis in southern China: analysis of 838 cases |
| title_full | Pediatric bacterial meningitis in southern China: analysis of 838 cases |
| title_fullStr | Pediatric bacterial meningitis in southern China: analysis of 838 cases |
| title_full_unstemmed | Pediatric bacterial meningitis in southern China: analysis of 838 cases |
| title_short | Pediatric bacterial meningitis in southern China: analysis of 838 cases |
| title_sort | pediatric bacterial meningitis in southern china analysis of 838 cases |
| topic | bacterial meningitis clinical features children prognosis risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1481716/full |
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