Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease
Objectives. To evaluate whether serum interleukin-6 (IL-6) is associated with increased risk of mortality in coronary artery disease (CAD) patients. Methods. We performed a prospective cohort study of 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC) study. Multivariable-adjus...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/726178 |
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| author | Dongfang Su Zhongxia Li Xinrui Li Yuming Chen Yuan Zhang Ding Ding Xueqing Deng Min Xia Jian Qiu Wenhua Ling |
| author_facet | Dongfang Su Zhongxia Li Xinrui Li Yuming Chen Yuan Zhang Ding Ding Xueqing Deng Min Xia Jian Qiu Wenhua Ling |
| author_sort | Dongfang Su |
| collection | DOAJ |
| description | Objectives. To evaluate whether serum interleukin-6 (IL-6) is associated with increased risk of mortality in coronary artery disease (CAD) patients. Methods. We performed a prospective cohort study of 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC) study. Multivariable-adjusted Cox proportional hazards regression analyses were used to examine the association between serum IL-6 with all-cause and cardiovascular mortality. Results. During the 1663 person-years of followup, the cumulative all-cause mortality and cardiovascular mortality were 6.5% (n=47) and 3.3% (n=24), respectively. The mean length of followup was 2.32±0.81 years. In the multivariable analyses, a one-SD increment in log-transformed serum IL-6 was positively associated with an increased risk of all-cause and cardiovascular mortality, with hazard ratios (HR) of 2.93 (95% CI, 2.11–4.08) and 2.04 (95% CI, 1.34–3.68) within the patients combined and 2.98 (95% CI, 2.12–4.18) and 3.10 (95% CI, 1.98–4.85) within males, respectively. Patients in the highest serum IL-6 tertile versus the lowest tertile were at higher risk of all-cause and cardiovascular mortality, with HR of 17.12 (95% CI 3.11–71.76) and 8.68 (95% CI, 1.88–37.51), respectively. Conclusions. In hospitalized patients with CAD, serum IL-6 is significantly associated with all-cause and cardiovascular mortality. |
| format | Article |
| id | doaj-art-fa26744c0c3c4875889d0293e70ef486 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fa26744c0c3c4875889d0293e70ef4862025-08-20T03:20:03ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/726178726178Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery DiseaseDongfang Su0Zhongxia Li1Xinrui Li2Yuming Chen3Yuan Zhang4Ding Ding5Xueqing Deng6Min Xia7Jian Qiu8Wenhua Ling9Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaDepartment of Cardiology, Guangzhou Military General Hospital, Number 111 Liuhua Road, Guangzhou, Guangdong 510010, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaDepartment of Cardiology, Guangzhou Military General Hospital, Number 111 Liuhua Road, Guangzhou, Guangdong 510010, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, ChinaObjectives. To evaluate whether serum interleukin-6 (IL-6) is associated with increased risk of mortality in coronary artery disease (CAD) patients. Methods. We performed a prospective cohort study of 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC) study. Multivariable-adjusted Cox proportional hazards regression analyses were used to examine the association between serum IL-6 with all-cause and cardiovascular mortality. Results. During the 1663 person-years of followup, the cumulative all-cause mortality and cardiovascular mortality were 6.5% (n=47) and 3.3% (n=24), respectively. The mean length of followup was 2.32±0.81 years. In the multivariable analyses, a one-SD increment in log-transformed serum IL-6 was positively associated with an increased risk of all-cause and cardiovascular mortality, with hazard ratios (HR) of 2.93 (95% CI, 2.11–4.08) and 2.04 (95% CI, 1.34–3.68) within the patients combined and 2.98 (95% CI, 2.12–4.18) and 3.10 (95% CI, 1.98–4.85) within males, respectively. Patients in the highest serum IL-6 tertile versus the lowest tertile were at higher risk of all-cause and cardiovascular mortality, with HR of 17.12 (95% CI 3.11–71.76) and 8.68 (95% CI, 1.88–37.51), respectively. Conclusions. In hospitalized patients with CAD, serum IL-6 is significantly associated with all-cause and cardiovascular mortality.http://dx.doi.org/10.1155/2013/726178 |
| spellingShingle | Dongfang Su Zhongxia Li Xinrui Li Yuming Chen Yuan Zhang Ding Ding Xueqing Deng Min Xia Jian Qiu Wenhua Ling Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease Mediators of Inflammation |
| title | Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease |
| title_full | Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease |
| title_fullStr | Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease |
| title_full_unstemmed | Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease |
| title_short | Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease |
| title_sort | association between serum interleukin 6 concentration and mortality in patients with coronary artery disease |
| url | http://dx.doi.org/10.1155/2013/726178 |
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