Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease
Abstract Millions of people worldwide have inflammatory bowel disease (IBD). Self‐driven micro/nanorobots (MNRs) are efficient in the treatment of IBD. However, their lack of controllability regarding direction of motion in the organism and their inability to achieve continuous navigation limits the...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202503307 |
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| author | Ying Feng Yang Liu Linlin Liu Qian Yang Miao An Huaming Yang |
| author_facet | Ying Feng Yang Liu Linlin Liu Qian Yang Miao An Huaming Yang |
| author_sort | Ying Feng |
| collection | DOAJ |
| description | Abstract Millions of people worldwide have inflammatory bowel disease (IBD). Self‐driven micro/nanorobots (MNRs) are efficient in the treatment of IBD. However, their lack of controllability regarding direction of motion in the organism and their inability to achieve continuous navigation limits their further application. In this study, polydopamine is wrapped around the magnetite surface, loaded with an anti‐inflammatory drug resveratrol, and wrapped with pH‐responsive sodium alginate to obtain magnetic MNRs. MNRs can be driven by magnetic fields to achieve directional movement and targeted transportation. In addition, MNRs can effectively remove reactive oxygen species from the inflammation site, repair intestinal damage, inhibit the cellular pathway of pro‐inflammatory factors, such as MAPK and NF‐κB pathways, and restore intestinal flora, thereby relieving IBDs. MNRs are safe and effective for in vivo treatment of IBD and have proven to be a promising therapeutic platform. This MNRs therapeutic strategy provides new insights into comprehensive IBD therapy. |
| format | Article |
| id | doaj-art-fa1d6c41723e4409b992c5bc9543e585 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-fa1d6c41723e4409b992c5bc9543e5852025-08-20T04:01:01ZengWileyAdvanced Science2198-38442025-07-011226n/an/a10.1002/advs.202503307Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel DiseaseYing Feng0Yang Liu1Linlin Liu2Qian Yang3Miao An4Huaming Yang5Engineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 ChinaEngineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 ChinaEngineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 ChinaCentre for Immune‐oncology Nuffield Department of Medicine University of Oxford Old Road Campus Oxford OX3 7BN UKEngineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 ChinaEngineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 ChinaAbstract Millions of people worldwide have inflammatory bowel disease (IBD). Self‐driven micro/nanorobots (MNRs) are efficient in the treatment of IBD. However, their lack of controllability regarding direction of motion in the organism and their inability to achieve continuous navigation limits their further application. In this study, polydopamine is wrapped around the magnetite surface, loaded with an anti‐inflammatory drug resveratrol, and wrapped with pH‐responsive sodium alginate to obtain magnetic MNRs. MNRs can be driven by magnetic fields to achieve directional movement and targeted transportation. In addition, MNRs can effectively remove reactive oxygen species from the inflammation site, repair intestinal damage, inhibit the cellular pathway of pro‐inflammatory factors, such as MAPK and NF‐κB pathways, and restore intestinal flora, thereby relieving IBDs. MNRs are safe and effective for in vivo treatment of IBD and have proven to be a promising therapeutic platform. This MNRs therapeutic strategy provides new insights into comprehensive IBD therapy.https://doi.org/10.1002/advs.202503307inflammatory bowel diseaseintestinal milieu restorationmicro/nanorobotsresveratrolROS scavenger |
| spellingShingle | Ying Feng Yang Liu Linlin Liu Qian Yang Miao An Huaming Yang Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease Advanced Science inflammatory bowel disease intestinal milieu restoration micro/nanorobots resveratrol ROS scavenger |
| title | Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease |
| title_full | Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease |
| title_fullStr | Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease |
| title_full_unstemmed | Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease |
| title_short | Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease |
| title_sort | magnetite micro nanorobots for efficient targeted alleviation of inflammatory bowel disease |
| topic | inflammatory bowel disease intestinal milieu restoration micro/nanorobots resveratrol ROS scavenger |
| url | https://doi.org/10.1002/advs.202503307 |
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