Ion-selective electrode-based sensors from the macro- to the nanoscale
Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights re...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Sensors and Actuators Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053924000742 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850065095158136832 |
|---|---|
| author | Yerim Kim Minjee Seo Seol Baek |
| author_facet | Yerim Kim Minjee Seo Seol Baek |
| author_sort | Yerim Kim |
| collection | DOAJ |
| description | Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights recent advancements in ionophore-based polymeric ISE sensors over the past five years, with a particular focus on progress at the micro- and nanoscales. After discussing the conventional ISE configuration and its general operational principles, we explore the notable advancements in terms of the key ion-selective membrane components, such as ionophores, and other techniques combined with ISEs. These advancements have significantly improved the sensing performances and expanded the practical applications. We also examine the progress in the field of miniaturized solid-contact microelectrodes and the incorporation of novel functional materials for efficient ion-to-electron transduction. Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. When combined with scanning electrochemical microscopy, ion-selective microelectrodes enable highly spatially resolved ion analyses. The integration of solid-contact ISEs into compact, portable, wearable devices has advanced the field of wearable on-body ISE sensors. Finally, we briefly introduce the development of ion-selective optode sensors as promising optical sensors based on ionophores that are particularly advantageous for cellular imaging. |
| format | Article |
| id | doaj-art-fa1d18fe52fd4d3e814f1b2358a8bbc7 |
| institution | DOAJ |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-fa1d18fe52fd4d3e814f1b2358a8bbc72025-08-20T02:49:05ZengElsevierSensors and Actuators Reports2666-05392025-06-01910025810.1016/j.snr.2024.100258Ion-selective electrode-based sensors from the macro- to the nanoscaleYerim Kim0Minjee Seo1Seol Baek2Department of Chemistry, Sookmyung Women's University, Seoul 04310, South KoreaDepartment of Chemistry Education, Korea National University of Education, Cheongju-si, Chungbuk 28173, South KoreaDepartment of Chemistry, Sookmyung Women's University, Seoul 04310, South Korea; Corresponding author at: Department of Chemistry, Sookmyung Women's University, Seoul 04310, South Korea.Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights recent advancements in ionophore-based polymeric ISE sensors over the past five years, with a particular focus on progress at the micro- and nanoscales. After discussing the conventional ISE configuration and its general operational principles, we explore the notable advancements in terms of the key ion-selective membrane components, such as ionophores, and other techniques combined with ISEs. These advancements have significantly improved the sensing performances and expanded the practical applications. We also examine the progress in the field of miniaturized solid-contact microelectrodes and the incorporation of novel functional materials for efficient ion-to-electron transduction. Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. When combined with scanning electrochemical microscopy, ion-selective microelectrodes enable highly spatially resolved ion analyses. The integration of solid-contact ISEs into compact, portable, wearable devices has advanced the field of wearable on-body ISE sensors. Finally, we briefly introduce the development of ion-selective optode sensors as promising optical sensors based on ionophores that are particularly advantageous for cellular imaging.http://www.sciencedirect.com/science/article/pii/S2666053924000742Ion-selective electrodesElectrochemical sensorsPotentiometric sensorsMicrosensorsNanosensorsMultiplexed sensors |
| spellingShingle | Yerim Kim Minjee Seo Seol Baek Ion-selective electrode-based sensors from the macro- to the nanoscale Sensors and Actuators Reports Ion-selective electrodes Electrochemical sensors Potentiometric sensors Microsensors Nanosensors Multiplexed sensors |
| title | Ion-selective electrode-based sensors from the macro- to the nanoscale |
| title_full | Ion-selective electrode-based sensors from the macro- to the nanoscale |
| title_fullStr | Ion-selective electrode-based sensors from the macro- to the nanoscale |
| title_full_unstemmed | Ion-selective electrode-based sensors from the macro- to the nanoscale |
| title_short | Ion-selective electrode-based sensors from the macro- to the nanoscale |
| title_sort | ion selective electrode based sensors from the macro to the nanoscale |
| topic | Ion-selective electrodes Electrochemical sensors Potentiometric sensors Microsensors Nanosensors Multiplexed sensors |
| url | http://www.sciencedirect.com/science/article/pii/S2666053924000742 |
| work_keys_str_mv | AT yerimkim ionselectiveelectrodebasedsensorsfromthemacrotothenanoscale AT minjeeseo ionselectiveelectrodebasedsensorsfromthemacrotothenanoscale AT seolbaek ionselectiveelectrodebasedsensorsfromthemacrotothenanoscale |