Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease

Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease

The mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing the entorhinal cortex in Alzheimer's disease (AD) is unknown. Here, we used in situ sequencing to...

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Bibliographic Details
Main Authors:	Zachery D. Morrissey, Pavan Kumar, Trongha X. Phan, Mark Maienschein-Cline, Alex Leow, Orly Lazarov
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Dementia
Subjects:	Alzheimer's disease neurogenesis spatial transcriptomics hippocampus adult hippocampal neurogenesis
Online Access:	https://www.frontiersin.org/articles/10.3389/frdem.2025.1546433/full
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