Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease
The mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing the entorhinal cortex in Alzheimer's disease (AD) is unknown. Here, we used in situ sequencing to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Dementia |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frdem.2025.1546433/full |
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| author | Zachery D. Morrissey Zachery D. Morrissey Zachery D. Morrissey Pavan Kumar Trongha X. Phan Mark Maienschein-Cline Alex Leow Alex Leow Orly Lazarov |
| author_facet | Zachery D. Morrissey Zachery D. Morrissey Zachery D. Morrissey Pavan Kumar Trongha X. Phan Mark Maienschein-Cline Alex Leow Alex Leow Orly Lazarov |
| author_sort | Zachery D. Morrissey |
| collection | DOAJ |
| description | The mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing the entorhinal cortex in Alzheimer's disease (AD) is unknown. Here, we used in situ sequencing to investigate the spatial transcription profile of neurons and glia in the hippocampal circuitry in wild-type mice and in familial AD (FAD) mice expressing varying levels of neurogenesis. This approach revealed that in addition to the dentate gyrus, neurogenesis modulates the cellular profile in the entorhinal cortex and CA regions of the hippocampus. Notably, enhancing neurogenesis in FAD mice led to partial restoration of neuronal and cellular profile in these brain areas, resembling the profile of their wild-type counterparts. This approach provides a platform for the examination of the cellular dynamics in the hippocampal formation in health and in AD. |
| format | Article |
| id | doaj-art-fa13ca121a154c49b20188c3bf5e16c6 |
| institution | OA Journals |
| issn | 2813-3919 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dementia |
| spelling | doaj-art-fa13ca121a154c49b20188c3bf5e16c62025-08-20T02:17:34ZengFrontiers Media S.A.Frontiers in Dementia2813-39192025-04-01410.3389/frdem.2025.15464331546433Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's diseaseZachery D. Morrissey0Zachery D. Morrissey1Zachery D. Morrissey2Pavan Kumar3Trongha X. Phan4Mark Maienschein-Cline5Alex Leow6Alex Leow7Orly Lazarov8Graduate Program in Neuroscience, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United StatesResearch Informatics Core, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, United StatesDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL, United StatesThe mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing the entorhinal cortex in Alzheimer's disease (AD) is unknown. Here, we used in situ sequencing to investigate the spatial transcription profile of neurons and glia in the hippocampal circuitry in wild-type mice and in familial AD (FAD) mice expressing varying levels of neurogenesis. This approach revealed that in addition to the dentate gyrus, neurogenesis modulates the cellular profile in the entorhinal cortex and CA regions of the hippocampus. Notably, enhancing neurogenesis in FAD mice led to partial restoration of neuronal and cellular profile in these brain areas, resembling the profile of their wild-type counterparts. This approach provides a platform for the examination of the cellular dynamics in the hippocampal formation in health and in AD.https://www.frontiersin.org/articles/10.3389/frdem.2025.1546433/fullAlzheimer's diseaseneurogenesisspatial transcriptomicshippocampusadult hippocampal neurogenesis |
| spellingShingle | Zachery D. Morrissey Zachery D. Morrissey Zachery D. Morrissey Pavan Kumar Trongha X. Phan Mark Maienschein-Cline Alex Leow Alex Leow Orly Lazarov Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease Frontiers in Dementia Alzheimer's disease neurogenesis spatial transcriptomics hippocampus adult hippocampal neurogenesis |
| title | Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease |
| title_full | Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease |
| title_fullStr | Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease |
| title_full_unstemmed | Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease |
| title_short | Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease |
| title_sort | neurogenesis drives hippocampal formation wide spatial transcription alterations in health and alzheimer s disease |
| topic | Alzheimer's disease neurogenesis spatial transcriptomics hippocampus adult hippocampal neurogenesis |
| url | https://www.frontiersin.org/articles/10.3389/frdem.2025.1546433/full |
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