Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges
This study reviewed the bioaccessibility of methylmercury and potentially toxic elements at trace or essential levels in seafood, through in vitro simulation. It highlights how variables such as shellfish species, geographic origin, and consumption form influence the bioaccessibility of these elemen...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Applied Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772502225002860 |
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| author | Leonardo Dias Nascimento André Luiz Sampaio da Silva Junior Gregório Mateus Santana Herick Macedo Santos Maria Graças Andrade Korn Rafaella Regina Alves Peixoto Raildo Mota de Jesus |
| author_facet | Leonardo Dias Nascimento André Luiz Sampaio da Silva Junior Gregório Mateus Santana Herick Macedo Santos Maria Graças Andrade Korn Rafaella Regina Alves Peixoto Raildo Mota de Jesus |
| author_sort | Leonardo Dias Nascimento |
| collection | DOAJ |
| description | This study reviewed the bioaccessibility of methylmercury and potentially toxic elements at trace or essential levels in seafood, through in vitro simulation. It highlights how variables such as shellfish species, geographic origin, and consumption form influence the bioaccessibility of these elements in the samples. For this purpose, a detailed literature was searched in Scopus, Web of Science™, PubMed® and Science Direct®, where 56 eligible articles (published between January 2014 and August 2024) from different regions were selected. The results highlighted a focus on methylmercury and potentially toxic elements at trace levels in shellfish, such as arsenic, cadmium, lead and mercury, which pose significant risks to human health. Culinary preparation methods can affect the bioaccessibility of these elements, showing the importance of considering these aspects when assessing food safety. The review highlighted the lack of standardization in analysis methodologies, pointing out the need for uniform guidelines to ensure replicability and the possibility of comparison between the results obtained. The introduction of the INFOGEST protocol was a significant advance in this regard, but its adoption is still limited among the studies reviewed. Furthermore, challenges and future perspectives were discussed, including the need to assess the real clinical impacts of exposure to methylmercury and elements in populations that consume seafood. |
| format | Article |
| id | doaj-art-fa11be2099124c09b7b2a2b215c5880c |
| institution | DOAJ |
| issn | 2772-5022 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Food Research |
| spelling | doaj-art-fa11be2099124c09b7b2a2b215c5880c2025-08-20T03:20:16ZengElsevierApplied Food Research2772-50222025-06-015110097810.1016/j.afres.2025.100978Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challengesLeonardo Dias Nascimento0André Luiz Sampaio da Silva Junior1Gregório Mateus Santana2Herick Macedo Santos3Maria Graças Andrade Korn4Rafaella Regina Alves Peixoto5Raildo Mota de Jesus6Programa de Pós-graduação em Desenvolvimento e Meio Ambiente, Universidade Estadual de Santa Cruz - UESC Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, BA, Brazil; Instituto Federal da Bahia -IFBA, Campus Porto Seguro, Rodovia Br 367, Km 57,5, 45810-000, Porto Seguro, Bahia, Brazil; Corresponding author at: Rod. Jorge Amado, km 16, Ilhéus, BA, CEP: 45655-142, Brazil.Programa de Pós-graduação em Desenvolvimento e Meio Ambiente, Universidade Estadual de Santa Cruz - UESC Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, BA, BrazilPrograma de Pós-graduação em Desenvolvimento e Meio Ambiente, Universidade Estadual de Santa Cruz - UESC Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, BA, BrazilDepartamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz - UESC, Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, Bahia, BrazilDepartamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia - UFBA, Campus Universitário de Ondina, 40170-115, Salvador, Bahia, Brazil; INCT de Energia e Ambiente, Instituto de Química, Universidade Federal da Bahia, Campus Universitário de Ondina, 40170-115, Salvador, Bahia, BrazilDepartment of Analytical Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, 13083-970, BrazilPrograma de Pós-graduação em Desenvolvimento e Meio Ambiente, Universidade Estadual de Santa Cruz - UESC Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, BA, Brazil; Departamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz - UESC, Rodovia Jorge Amado, Km 16, 45662-900, Ilhéus, Bahia, Brazil; INCT de Energia e Ambiente, Instituto de Química, Universidade Federal da Bahia, Campus Universitário de Ondina, 40170-115, Salvador, Bahia, Brazil; Corresponding author at: Rod. Jorge Amado, km 16, Ilhéus, BA, CEP: 45655-142, Brazil.This study reviewed the bioaccessibility of methylmercury and potentially toxic elements at trace or essential levels in seafood, through in vitro simulation. It highlights how variables such as shellfish species, geographic origin, and consumption form influence the bioaccessibility of these elements in the samples. For this purpose, a detailed literature was searched in Scopus, Web of Science™, PubMed® and Science Direct®, where 56 eligible articles (published between January 2014 and August 2024) from different regions were selected. The results highlighted a focus on methylmercury and potentially toxic elements at trace levels in shellfish, such as arsenic, cadmium, lead and mercury, which pose significant risks to human health. Culinary preparation methods can affect the bioaccessibility of these elements, showing the importance of considering these aspects when assessing food safety. The review highlighted the lack of standardization in analysis methodologies, pointing out the need for uniform guidelines to ensure replicability and the possibility of comparison between the results obtained. The introduction of the INFOGEST protocol was a significant advance in this regard, but its adoption is still limited among the studies reviewed. Furthermore, challenges and future perspectives were discussed, including the need to assess the real clinical impacts of exposure to methylmercury and elements in populations that consume seafood.http://www.sciencedirect.com/science/article/pii/S2772502225002860Bioaccessible fractionToxic trace metalsToxicitySeafoodBivalve |
| spellingShingle | Leonardo Dias Nascimento André Luiz Sampaio da Silva Junior Gregório Mateus Santana Herick Macedo Santos Maria Graças Andrade Korn Rafaella Regina Alves Peixoto Raildo Mota de Jesus Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges Applied Food Research Bioaccessible fraction Toxic trace metals Toxicity Seafood Bivalve |
| title | Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges |
| title_full | Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges |
| title_fullStr | Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges |
| title_full_unstemmed | Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges |
| title_short | Bioaccessibility of methylmercury, potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation: perspectives and challenges |
| title_sort | bioaccessibility of methylmercury potentially toxic elements at trace or essential levels in seafood by in vitro gastrointestinal simulation perspectives and challenges |
| topic | Bioaccessible fraction Toxic trace metals Toxicity Seafood Bivalve |
| url | http://www.sciencedirect.com/science/article/pii/S2772502225002860 |
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