Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans
Photodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the ef...
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MDPI AG
2024-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/12/363 |
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| author | Yasuo Komura Shintarou Kimura Yumi Hirasawa Tomoko Katagiri Ayana Takaura Fumika Yoshida Saki Fukuro Hiromi Muranishi Osamu Imataki Koichiro Homma |
| author_facet | Yasuo Komura Shintarou Kimura Yumi Hirasawa Tomoko Katagiri Ayana Takaura Fumika Yoshida Saki Fukuro Hiromi Muranishi Osamu Imataki Koichiro Homma |
| author_sort | Yasuo Komura |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the efficacy of IR-783 in cell and animal studies, its efficacy in clinical settings remains unknown. Therefore, we aimed to determine the efficacy of PDT using IR-783 liposomes. An HMC dye, excited by long-wavelength infrared light and with high tissue permeability, was used for PDT after liposomization to enhance tumor tissue accumulation. PDT was performed using IR-783 in two patients with either tongue or breast cancer, one each. IR-783 liposomes inhibited cell proliferation in tongue cancer cells even when not excited by light. Tumor size was markedly reduced in both cases, with no significant adverse events. Furthermore, the patient with tongue cancer exhibited improved respiratory, swallowing, and speech functions, which were attributed not only to the shrinkage of the tumor but also to the improvement in airway narrowing. In conclusion, PDT using IR-783 liposomes effectively reduces tumor size in tongue and breast cancers. |
| format | Article |
| id | doaj-art-fa0f864234d64facb6899dd37123b2e8 |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-fa0f864234d64facb6899dd37123b2e82025-08-20T02:55:57ZengMDPI AGJournal of Functional Biomaterials2079-49832024-12-01151236310.3390/jfb15120363Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in HumansYasuo Komura0Shintarou Kimura1Yumi Hirasawa2Tomoko Katagiri3Ayana Takaura4Fumika Yoshida5Saki Fukuro6Hiromi Muranishi7Osamu Imataki8Koichiro Homma9Rinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, JapanStateArt Inc., 2-9-12 Horidome-cho, Nihonbashi, Chuo-ku, Tokyo 103-0012, JapanStateArt Inc., 2-9-12 Horidome-cho, Nihonbashi, Chuo-ku, Tokyo 103-0012, JapanStateArt Inc., 2-9-12 Horidome-cho, Nihonbashi, Chuo-ku, Tokyo 103-0012, JapanRinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, JapanRinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, JapanRinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, JapanRinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, JapanFaculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun 761-0793, JapanDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanPhotodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the efficacy of IR-783 in cell and animal studies, its efficacy in clinical settings remains unknown. Therefore, we aimed to determine the efficacy of PDT using IR-783 liposomes. An HMC dye, excited by long-wavelength infrared light and with high tissue permeability, was used for PDT after liposomization to enhance tumor tissue accumulation. PDT was performed using IR-783 in two patients with either tongue or breast cancer, one each. IR-783 liposomes inhibited cell proliferation in tongue cancer cells even when not excited by light. Tumor size was markedly reduced in both cases, with no significant adverse events. Furthermore, the patient with tongue cancer exhibited improved respiratory, swallowing, and speech functions, which were attributed not only to the shrinkage of the tumor but also to the improvement in airway narrowing. In conclusion, PDT using IR-783 liposomes effectively reduces tumor size in tongue and breast cancers.https://www.mdpi.com/2079-4983/15/12/363breast cancerheptamethine cyanine dyesindocyanine greenIR-783liposomelung cancer cells |
| spellingShingle | Yasuo Komura Shintarou Kimura Yumi Hirasawa Tomoko Katagiri Ayana Takaura Fumika Yoshida Saki Fukuro Hiromi Muranishi Osamu Imataki Koichiro Homma Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans Journal of Functional Biomaterials breast cancer heptamethine cyanine dyes indocyanine green IR-783 liposome lung cancer cells |
| title | Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans |
| title_full | Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans |
| title_fullStr | Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans |
| title_full_unstemmed | Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans |
| title_short | Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans |
| title_sort | photodynamic therapy using ir 783 liposomes for advanced tongue and breast cancers in humans |
| topic | breast cancer heptamethine cyanine dyes indocyanine green IR-783 liposome lung cancer cells |
| url | https://www.mdpi.com/2079-4983/15/12/363 |
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