Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
Abstract The anterior cingulate cortex (ACC) is essential for social behavior, and its dysfunction is implicated in social interaction deficits in autism. Pyramidal neuron activity in the ACC is modulated by parvalbumin (PV) and somatostatin (SST) interneurons, though their specific roles in social...
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Nature Portfolio
2025-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59473-z |
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| author | Chuchu Qi Wenqi Sima Honghui Mao Erling Hu Junye Ge Mao Deng Andi Chen Weiyi Ye Qian Xue Wenting Wang Qian Chen Shengxi Wu |
| author_facet | Chuchu Qi Wenqi Sima Honghui Mao Erling Hu Junye Ge Mao Deng Andi Chen Weiyi Ye Qian Xue Wenting Wang Qian Chen Shengxi Wu |
| author_sort | Chuchu Qi |
| collection | DOAJ |
| description | Abstract The anterior cingulate cortex (ACC) is essential for social behavior, and its dysfunction is implicated in social interaction deficits in autism. Pyramidal neuron activity in the ACC is modulated by parvalbumin (PV) and somatostatin (SST) interneurons, though their specific roles in social interactions remain unclear. Here, we demonstrate that PV and SST interneurons differentially contribute to the regulation of social interactions. In a Shank3-deficient autistic model, the expression of Kcnh7, a risk gene for autism, is reduced in both PV and SST interneurons. Knocking out Kcnh7 in either interneuron subtype leads to social interaction deficits. Furthermore, projections from the lateral posterior thalamic nucleus (mediorostral part, LPMR) to PV interneurons and from the ventral hippocampus (vHPC) to SST interneurons differentially modulate social interactions. These findings provide new insights into the distinct roles of PV and SST interneurons in social processes and their contributions to autism-related pathophysiology. |
| format | Article |
| id | doaj-art-fa0e214ef2e5443e8c1845dc2e7c0c26 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-fa0e214ef2e5443e8c1845dc2e7c0c262025-08-20T03:52:55ZengNature PortfolioNature Communications2041-17232025-05-0116111810.1038/s41467-025-59473-zAnterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male miceChuchu Qi0Wenqi Sima1Honghui Mao2Erling Hu3Junye Ge4Mao Deng5Andi Chen6Weiyi Ye7Qian Xue8Wenting Wang9Qian Chen10Shengxi Wu11Department of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical UniversityAbstract The anterior cingulate cortex (ACC) is essential for social behavior, and its dysfunction is implicated in social interaction deficits in autism. Pyramidal neuron activity in the ACC is modulated by parvalbumin (PV) and somatostatin (SST) interneurons, though their specific roles in social interactions remain unclear. Here, we demonstrate that PV and SST interneurons differentially contribute to the regulation of social interactions. In a Shank3-deficient autistic model, the expression of Kcnh7, a risk gene for autism, is reduced in both PV and SST interneurons. Knocking out Kcnh7 in either interneuron subtype leads to social interaction deficits. Furthermore, projections from the lateral posterior thalamic nucleus (mediorostral part, LPMR) to PV interneurons and from the ventral hippocampus (vHPC) to SST interneurons differentially modulate social interactions. These findings provide new insights into the distinct roles of PV and SST interneurons in social processes and their contributions to autism-related pathophysiology.https://doi.org/10.1038/s41467-025-59473-z |
| spellingShingle | Chuchu Qi Wenqi Sima Honghui Mao Erling Hu Junye Ge Mao Deng Andi Chen Weiyi Ye Qian Xue Wenting Wang Qian Chen Shengxi Wu Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice Nature Communications |
| title | Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| title_full | Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| title_fullStr | Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| title_full_unstemmed | Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| title_short | Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| title_sort | anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice |
| url | https://doi.org/10.1038/s41467-025-59473-z |
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