Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis

Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis

Macrophage apoptosis, along with inflammation in the interface membrane, has been demonstrated to be significant in the pathogenesis and development of particle-induced periprosthetic osteolysis and aseptic loosening. Additionally, the apoptosis of macrophages is considered an indicator of the resol...

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Bibliographic Details
Main Authors: Guoyin Liu, Haiyang Gong, Tianting Bai, Yahui Fu, Xin Li, Junhao Lu, Jianning Zhao, Jianmin Chen
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Bioengineering
Subjects:
osteolysis
aseptic loosening
wear particles
4-phenylbutyrate
apoptosis
inflammation
Online Access:https://www.mdpi.com/2306-5354/12/7/701
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