Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction

Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction

Abstract Dysfunction of cytotoxic T cells (CTL) remains a major cause of tumor immune evasion and is correlated with poor cancer survival. Here, we found that increased soluble form of ICOSL (sICOSL) induced CTL dysfunction and was associated with shorter survival of patients with breast cancer. sIC...

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Main Authors: Zhenghao Wu, Peng Zheng, Ruobing Qi, Yunxiao Xiao, Zihan Xi, Lei Dai, Tao Chen, Qianheng Wang, Furong Zhang, Rong Wang, Zimei Tang, Xiangwang Zhao, Jie Tan, Jie Ming, Ping Lei, Chunping Liu, Tao Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Experimental Hematology & Oncology
Subjects:
Breast cancer
Cytotoxic T cells
Immune evasion
Protein targeted degradation
ICOSL
Online Access:https://doi.org/10.1186/s40164-025-00692-x
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