KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is needed, since current therapy is limited to neurosurgery. Familial CCM is caused by loss‐of‐function mutations in...

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Main Authors: Roberto Cuttano, Noemi Rudini, Luca Bravi, Monica Corada, Costanza Giampietro, Eleanna Papa, Marco Francesco Morini, Luigi Maddaluno, Nicolas Baeyens, Ralf H Adams, Mukesh K Jain, Gary K Owens, Martin Schwartz, Maria Grazia Lampugnani, Elisabetta Dejana
Format: Article
Language:English
Published: Springer Nature 2015-11-01
Series:EMBO Molecular Medicine
Subjects:
CCM
EndMT
endothelial cells
KLF4
TGFβ‐BMP
Online Access:https://doi.org/10.15252/emmm.201505433
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