Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review
Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug r...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/6353919 |
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| author | Bahareh Abtahi-Naeini Tooba Momen Rezvan Amiri Parvin Rajabi Fereshte Rastegarnasab |
| author_facet | Bahareh Abtahi-Naeini Tooba Momen Rezvan Amiri Parvin Rajabi Fereshte Rastegarnasab |
| author_sort | Bahareh Abtahi-Naeini |
| collection | DOAJ |
| description | Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug reactions for proper diagnosis and treatment. Herein, we report a 43-year-old man with generalized bullous lesions with a positive dechallenge-rechallenge test diagnosed as metformin-induced generalized bullous fixed-drug eruption. Metformin dosage was stopped and lesions were treated with topical clobetasol propionate and oral prednisolone and cyclosporine-A. After a 6-month follow-up, he was well without any relapsing episodes. |
| format | Article |
| id | doaj-art-fa096edb7bd441f6925eee373e1eae47 |
| institution | DOAJ |
| issn | 2090-6471 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-fa096edb7bd441f6925eee373e1eae472025-08-20T03:06:31ZengWileyCase Reports in Dermatological Medicine2090-64712023-01-01202310.1155/2023/6353919Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature ReviewBahareh Abtahi-Naeini0Tooba Momen1Rezvan Amiri2Parvin Rajabi3Fereshte Rastegarnasab4Pediatric Dermatology Division of Department of PediatricsDepartment of AsthmaLeishmaniasis Research CenterDepartment of PathologyStudent Research CommitteeMetformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug reactions for proper diagnosis and treatment. Herein, we report a 43-year-old man with generalized bullous lesions with a positive dechallenge-rechallenge test diagnosed as metformin-induced generalized bullous fixed-drug eruption. Metformin dosage was stopped and lesions were treated with topical clobetasol propionate and oral prednisolone and cyclosporine-A. After a 6-month follow-up, he was well without any relapsing episodes.http://dx.doi.org/10.1155/2023/6353919 |
| spellingShingle | Bahareh Abtahi-Naeini Tooba Momen Rezvan Amiri Parvin Rajabi Fereshte Rastegarnasab Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review Case Reports in Dermatological Medicine |
| title | Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review |
| title_full | Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review |
| title_fullStr | Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review |
| title_full_unstemmed | Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review |
| title_short | Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review |
| title_sort | metformin induced generalized bullous fixed drug eruption with a positive dechallenge rechallenge test a case report and literature review |
| url | http://dx.doi.org/10.1155/2023/6353919 |
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