Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women
Immunosenescence is a process of immune system remodeling based on the natural aging process. Factors such as diet, physical exercise, mental health, and genetic/metabolic conditions can influence the development of age-related inflammation. In senescence, overweight and obesity are silent inflammat...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Public Health |
| Online Access: | http://dx.doi.org/10.1155/2024/8267161 |
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| author | Débora Nonato Miranda de Toledo Priscilla Vilela dos Santos Nathalia Sernizon Guimarães Alessandra de Paula Carli Patrícia Regina Soares de Souza Luiza Oliveira Perucci Caio César de Souza Alves André Talvani |
| author_facet | Débora Nonato Miranda de Toledo Priscilla Vilela dos Santos Nathalia Sernizon Guimarães Alessandra de Paula Carli Patrícia Regina Soares de Souza Luiza Oliveira Perucci Caio César de Souza Alves André Talvani |
| author_sort | Débora Nonato Miranda de Toledo |
| collection | DOAJ |
| description | Immunosenescence is a process of immune system remodeling based on the natural aging process. Factors such as diet, physical exercise, mental health, and genetic/metabolic conditions can influence the development of age-related inflammation. In senescence, overweight and obesity are silent inflammatory conditions that predispose individuals to cardiovascular diseases and other comorbidities. This study aimed to evaluate the concentration of obesity-related plasma biomarkers (creatine kinase (CK), CXCL16, IL-33, leptin, and resistin) in clinically stable women of different ages and weights. A cross-sectional study was conducted in Minas Gerais State, Brazil, involving 54 women (aged 20–85 years), assisted by the Brazilian Public Health Service. Socioeconomic and anthropometric parameters were assessed, and plasma levels of CK, CXCL16, IL-33, leptin, and resistin were measured using immunological and biochemical assays. Out of the total study participants, 54 women (mean age 44.9 years) were overweight and presented high plasma levels of CK, CXCL16, IL-33, and leptin. Specifically, plasma CK levels were similar in adults, middle-aged, and elderly women, but there was an increase in its release associated with overweight in adults and elderly women. Plasma IL-33, CXCL16, and resistin were reduced in elderly clinically stable women but not leptin. However, when volunteers were grouped according to body mass index, CXCL16, IL-33, and leptin were elevated and associated with overweight. Together, plasma levels of CK, CXCL16, IL-33, and leptin were identified as promising indicators of immunosenescence, regardless of weight parameters. Moreover, CXCL16 levels evaluated as an isolated parameter were a stronger indicator of obesity, regardless of aging. |
| format | Article |
| id | doaj-art-fa0156f196234bb9a6c3656986fdd84f |
| institution | Kabale University |
| issn | 2314-7784 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Public Health |
| spelling | doaj-art-fa0156f196234bb9a6c3656986fdd84f2025-02-03T07:23:45ZengWileyAdvances in Public Health2314-77842024-01-01202410.1155/2024/8267161Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian WomenDébora Nonato Miranda de Toledo0Priscilla Vilela dos Santos1Nathalia Sernizon Guimarães2Alessandra de Paula Carli3Patrícia Regina Soares de Souza4Luiza Oliveira Perucci5Caio César de Souza Alves6André Talvani7Universidade Federal de Ouro PretoUniversidade Federal de Ouro PretoUniversidade Federal de Minas GeraisUniversidade Federal dos Vales do Jequitinhonha e MucuriUniversidade Federal de Ouro PretoUniversity of CaliforniaUniversidade Federal dos Vales do Jequitinhonha e MucuriUniversidade Federal de Ouro PretoImmunosenescence is a process of immune system remodeling based on the natural aging process. Factors such as diet, physical exercise, mental health, and genetic/metabolic conditions can influence the development of age-related inflammation. In senescence, overweight and obesity are silent inflammatory conditions that predispose individuals to cardiovascular diseases and other comorbidities. This study aimed to evaluate the concentration of obesity-related plasma biomarkers (creatine kinase (CK), CXCL16, IL-33, leptin, and resistin) in clinically stable women of different ages and weights. A cross-sectional study was conducted in Minas Gerais State, Brazil, involving 54 women (aged 20–85 years), assisted by the Brazilian Public Health Service. Socioeconomic and anthropometric parameters were assessed, and plasma levels of CK, CXCL16, IL-33, leptin, and resistin were measured using immunological and biochemical assays. Out of the total study participants, 54 women (mean age 44.9 years) were overweight and presented high plasma levels of CK, CXCL16, IL-33, and leptin. Specifically, plasma CK levels were similar in adults, middle-aged, and elderly women, but there was an increase in its release associated with overweight in adults and elderly women. Plasma IL-33, CXCL16, and resistin were reduced in elderly clinically stable women but not leptin. However, when volunteers were grouped according to body mass index, CXCL16, IL-33, and leptin were elevated and associated with overweight. Together, plasma levels of CK, CXCL16, IL-33, and leptin were identified as promising indicators of immunosenescence, regardless of weight parameters. Moreover, CXCL16 levels evaluated as an isolated parameter were a stronger indicator of obesity, regardless of aging.http://dx.doi.org/10.1155/2024/8267161 |
| spellingShingle | Débora Nonato Miranda de Toledo Priscilla Vilela dos Santos Nathalia Sernizon Guimarães Alessandra de Paula Carli Patrícia Regina Soares de Souza Luiza Oliveira Perucci Caio César de Souza Alves André Talvani Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women Advances in Public Health |
| title | Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women |
| title_full | Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women |
| title_fullStr | Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women |
| title_full_unstemmed | Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women |
| title_short | Plasma Inflammatory Biomarkers Indicative of Aging and Overweight in Brazilian Women |
| title_sort | plasma inflammatory biomarkers indicative of aging and overweight in brazilian women |
| url | http://dx.doi.org/10.1155/2024/8267161 |
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