Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma

Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma

Background The polarization status and function of tumor-associated macrophages (TAMs) influence tumor progression and patients’ prognosis. CCAAT/enhancer-binding proteins (CEBPs) family are important transcriptional factors in macrophages differentiation physically and pathologically. This study ai...

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Main Authors: Jun Gu, Yifan Liu, Wang Zhou, Shun Zhang, Ke-Qin Dong, Jia-Xin Chen, Wen-Yan Li, Zi-Chang Liu, Yi-Fan Tang, Xiu-Wu Pan, Xin-Gang Cui, Hong-feng Zheng, Mu-chen Li, Tian-yue Yang, Jian-gui Liu, Zi-xuan Gong
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e010898.full
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