Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner
The aim of this study is to simulate GE Discovery 690 VCT positron emission tomography/computed tomography (PET/CT) scanner using Geant4 Application for Tomographic Emission (GATE) simulation package (version 8). Then, we assess the performance of scanner by comparing measured and simulated paramete...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-10-01
|
| Series: | World Journal of Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_4_20 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228295400947712 |
|---|---|
| author | Elham Kashian Hadi Ahangari Vahab Dehlaghi Karim Khoshgard Pardis Ghafarian Raheb Ghorbani |
| author_facet | Elham Kashian Hadi Ahangari Vahab Dehlaghi Karim Khoshgard Pardis Ghafarian Raheb Ghorbani |
| author_sort | Elham Kashian |
| collection | DOAJ |
| description | The aim of this study is to simulate GE Discovery 690 VCT positron emission tomography/computed tomography (PET/CT) scanner using Geant4 Application for Tomographic Emission (GATE) simulation package (version 8). Then, we assess the performance of scanner by comparing measured and simulated parameter results. Detection system and geometry of PET scanner that consists of 13,824 LYSO crystals designed in 256 blocks and 24 ring detectors were modeled. In order to achieve a precise model, we verified scanner model. Validation was based on a comparison between simulation data and experimental results obtained with this scanner in the same situation. Parameters used for validation were sensitivity, spatial resolution, and contrast. Image quality assessment was done based on comparing the contrast recovery coefficient (CRC) of simulated and measured images. The findings demonstrate that the mean difference between simulated and measured sensitivity is <7%. The simulated spatial resolution agreed to within <5.5% of the measured values. Contrast results had a slight divergence within the range below 4%. The image quality validation study demonstrated an acceptable agreement in CRC for 8:1 and 2:1 source-to-background activity ratio. Validated performance parameters showed good agreement between experimental data and simulated results and demonstrated that GATE is a valid simulation tool for simulating this scanner model. The simulated model of this scanner can be used for future studies regarding optimization of image reconstruction algorithms and emission acquisition protocols. |
| format | Article |
| id | doaj-art-f9f395eb5bdf415d99d5f6765eecdfda |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-f9f395eb5bdf415d99d5f6765eecdfda2025-08-20T02:04:34ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122020-10-01190436637510.4103/wjnm.WJNM_4_20Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scannerElham Kashian0Hadi Ahangari1Vahab Dehlaghi2Karim Khoshgard3Pardis Ghafarian4Raheb Ghorbani5Department of Biomedical Engineering and Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, KermanshahDepartment of Medical Physics, Faculty of medicine, Semnan University of Medical Sciences, SemnanDepartment of Biomedical Engineering and Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, KermanshahDepartment of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, KermanshahChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)Department of Social Medicine, Faculty of medicine, Semnan University of Medical Sciences, SemnanThe aim of this study is to simulate GE Discovery 690 VCT positron emission tomography/computed tomography (PET/CT) scanner using Geant4 Application for Tomographic Emission (GATE) simulation package (version 8). Then, we assess the performance of scanner by comparing measured and simulated parameter results. Detection system and geometry of PET scanner that consists of 13,824 LYSO crystals designed in 256 blocks and 24 ring detectors were modeled. In order to achieve a precise model, we verified scanner model. Validation was based on a comparison between simulation data and experimental results obtained with this scanner in the same situation. Parameters used for validation were sensitivity, spatial resolution, and contrast. Image quality assessment was done based on comparing the contrast recovery coefficient (CRC) of simulated and measured images. The findings demonstrate that the mean difference between simulated and measured sensitivity is <7%. The simulated spatial resolution agreed to within <5.5% of the measured values. Contrast results had a slight divergence within the range below 4%. The image quality validation study demonstrated an acceptable agreement in CRC for 8:1 and 2:1 source-to-background activity ratio. Validated performance parameters showed good agreement between experimental data and simulated results and demonstrated that GATE is a valid simulation tool for simulating this scanner model. The simulated model of this scanner can be used for future studies regarding optimization of image reconstruction algorithms and emission acquisition protocols.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_4_20digital phantomgeant4 application for tomographic emissionmonte carlo simulationpositron emission tomography scannervalidation |
| spellingShingle | Elham Kashian Hadi Ahangari Vahab Dehlaghi Karim Khoshgard Pardis Ghafarian Raheb Ghorbani Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner World Journal of Nuclear Medicine digital phantom geant4 application for tomographic emission monte carlo simulation positron emission tomography scanner validation |
| title | Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner |
| title_full | Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner |
| title_fullStr | Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner |
| title_full_unstemmed | Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner |
| title_short | Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner |
| title_sort | monte carlo simulation and performance assessment of ge discovery 690 vct positron emission tomography computed tomography scanner |
| topic | digital phantom geant4 application for tomographic emission monte carlo simulation positron emission tomography scanner validation |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_4_20 |
| work_keys_str_mv | AT elhamkashian montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner AT hadiahangari montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner AT vahabdehlaghi montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner AT karimkhoshgard montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner AT pardisghafarian montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner AT rahebghorbani montecarlosimulationandperformanceassessmentofgediscovery690vctpositronemissiontomographycomputedtomographyscanner |