Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis
The gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack of comprehensive understanding of microbiome-host crosstalk. Here, we analyzed the influence of gut microbiome dynamics in early childhood on atopic dermatitis (AD) and the potential i...
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| Format: | Article |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2068366 |
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| author | Min-Jung Lee Yoon Mee Park Byunghyun Kim in Hwan Tae Nam-Eun Kim Marina Pranata Taewon Kim Sungho Won Nam Joo Kang Yun Kyung Lee Dong-Woo Lee Myung Hee Nam Soo-Jong Hong Bong-Soo Kim |
| author_facet | Min-Jung Lee Yoon Mee Park Byunghyun Kim in Hwan Tae Nam-Eun Kim Marina Pranata Taewon Kim Sungho Won Nam Joo Kang Yun Kyung Lee Dong-Woo Lee Myung Hee Nam Soo-Jong Hong Bong-Soo Kim |
| author_sort | Min-Jung Lee |
| collection | DOAJ |
| description | The gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack of comprehensive understanding of microbiome-host crosstalk. Here, we analyzed the influence of gut microbiome dynamics in early childhood on atopic dermatitis (AD) and the potential interactions between host and microbiome that control this homeostasis. We analyzed the gut microbiome in 346 fecal samples (6–36 months; 112 non-AD, 110 mild AD, and 124 moderate to severe AD) from the Longitudinal Cohort for Childhood Origin of Asthma and Allergic Disease birth cohort. The microbiome-host interactions were analyzed in animal and in vitro cell assays. Although the gut microbiome maturated with age in both AD and non-AD groups, its development was disordered in the AD group. Disordered colonization of short-chain fatty acids (SCFA) producers along with age led to abnormal SCFA production and increased IgE levels. A butyrate deficiency and downregulation of GPR109A and PPAR-γ genes were detected in AD-induced mice. Insufficient butyrate decreases the oxygen consumption rate of host cells, which can release oxygen to the gut and perturb the gut microbiome. The disordered gut microbiome development could aggravate balanced microbiome-host interactions, including immune responses during early childhood with AD. |
| format | Article |
| id | doaj-art-f9f052eb18cd4fcc95d5071928c5c8d3 |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-f9f052eb18cd4fcc95d5071928c5c8d32025-08-20T03:22:16ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2068366Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitisMin-Jung Lee0Yoon Mee Park1Byunghyun Kim2in Hwan Tae3Nam-Eun Kim4Marina Pranata5Taewon Kim6Sungho Won7Nam Joo Kang8Yun Kyung Lee9Dong-Woo Lee10Myung Hee Nam11Soo-Jong Hong12Bong-Soo Kim13Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of KoreaAsan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of KoreaSeoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaSeoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaDepartment of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheonan, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of KoreaDepartment of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of KoreaDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheonan, Republic of KoreaDepartment of Biotechnology, Yonsei University, Seoul, Republic of KoreaSeoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaDepartment of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of KoreaThe gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack of comprehensive understanding of microbiome-host crosstalk. Here, we analyzed the influence of gut microbiome dynamics in early childhood on atopic dermatitis (AD) and the potential interactions between host and microbiome that control this homeostasis. We analyzed the gut microbiome in 346 fecal samples (6–36 months; 112 non-AD, 110 mild AD, and 124 moderate to severe AD) from the Longitudinal Cohort for Childhood Origin of Asthma and Allergic Disease birth cohort. The microbiome-host interactions were analyzed in animal and in vitro cell assays. Although the gut microbiome maturated with age in both AD and non-AD groups, its development was disordered in the AD group. Disordered colonization of short-chain fatty acids (SCFA) producers along with age led to abnormal SCFA production and increased IgE levels. A butyrate deficiency and downregulation of GPR109A and PPAR-γ genes were detected in AD-induced mice. Insufficient butyrate decreases the oxygen consumption rate of host cells, which can release oxygen to the gut and perturb the gut microbiome. The disordered gut microbiome development could aggravate balanced microbiome-host interactions, including immune responses during early childhood with AD.https://www.tandfonline.com/doi/10.1080/19490976.2022.2068366Gutmicrobiomeatopic dermatitisdevelopmenthomeostasis |
| spellingShingle | Min-Jung Lee Yoon Mee Park Byunghyun Kim in Hwan Tae Nam-Eun Kim Marina Pranata Taewon Kim Sungho Won Nam Joo Kang Yun Kyung Lee Dong-Woo Lee Myung Hee Nam Soo-Jong Hong Bong-Soo Kim Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis Gut Microbes Gut microbiome atopic dermatitis development homeostasis |
| title | Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| title_full | Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| title_fullStr | Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| title_full_unstemmed | Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| title_short | Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| title_sort | disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis |
| topic | Gut microbiome atopic dermatitis development homeostasis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2068366 |
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