Molecular techniques for cancer diagnostics
Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia.edu Journals
2024-01-01
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| Series: | Academia Medicine |
| Online Access: | https://www.academia.edu/114247359/Molecular_techniques_for_cancer_diagnostics |
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| Summary: | Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and clinical approval of several drugs that are more efficient and can specifically target cancer-specific pathways to provide a long-lasting cure. Recent advancements in describing genetic alterations in human cancers are a tempting reason for scientists to develop more effective, personalized therapies as the next level of cancer treatment. However, the drug discovery process is tedious, and getting approval from various regulatory authorities may be more frustrating for a steady developmental pace. Among various prime regulators, the most critical challenge and priority in oncology research is to define unique molecular biomarkers, which would enhance the diagnosis. These molecular biomarkers should have the potential to beacon the prognostics, design, and monitoring of the newer therapeutics. Several key findings are being identified to discover and validate such molecular biomarkers for their diagnostic potential at the DNA, RNA, and protein levels. Furthermore, noninvasive imaging technologies and serum biomarkers are promising higher quality outputs in a limited time which could be a useful tool to monitor early responses to the treatment and may be able to design the remedial course. These advances would pave the way for personalized cancer therapeutics if translated beyond scientific discovery. This article highlights the various aspects of translational research and associated issues i.e. trial design, tissue collection, and regulatory requirements. |
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| ISSN: | 2994-435X |