Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study
Background: Concerns exist that long-term cardiac alterations occur after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, particularly in patients who were hospitalized in the acute phase or who remain symptomatic. This study investigates potential long-term functional a...
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| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724011517 |
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| author | Janek Salatzki Andreas Ochs Lukas D. Weberling Jannick Heins Marc Zahlten James G. Whayne Christian Stehning Evangelos Giannitsis Claudia M. Denkinger Uta Merle Sebastian J. Buss Henning Steen Florian André Norbert Frey |
| author_facet | Janek Salatzki Andreas Ochs Lukas D. Weberling Jannick Heins Marc Zahlten James G. Whayne Christian Stehning Evangelos Giannitsis Claudia M. Denkinger Uta Merle Sebastian J. Buss Henning Steen Florian André Norbert Frey |
| author_sort | Janek Salatzki |
| collection | DOAJ |
| description | Background: Concerns exist that long-term cardiac alterations occur after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, particularly in patients who were hospitalized in the acute phase or who remain symptomatic. This study investigates potential long-term functional and morphological alterations after SARS-CoV-2 infection. Methods: The authors of this study investigated patients after SARS-CoV-2 infection by using a mobile 1.5T clinical magnetic resonance scanner for cardiac alterations. Cardiac function and dimensions were assessed using a highly efficient cardiac magnetic resonance protocol, which included cine sequences, global longitudinal and circumferential strain assessed by fast-Strain-ENCoded imaging, and T1 and T2 mapping. We assessed symptoms through a questionnaire. Patients were compared with a control group matched for age, gender, body mass index, and body surface area. Results: Median follow-up time was 395 (192-408) days. The final population included 183 participants (age 48.4 ± 14.3 years, 48.1% male (88/183)). During the acute phase of SARS-CoV-2 infection, 27 patients were hospital-admitted. Forty-two patients reported persistent symptoms (shortness of breath, chest pain, palpitations, or leg edema), and 63 reported impaired exercise tolerance. Left ventricular (LV) functional and morphological parameters were within the normal range. T1- and T2-relaxation times were also within the normal range, indicating that the presence of myocardial edema or fibrosis was unlikely. Persistently symptomatic patients showed a slightly reduced indexed LV stroke volume. Functional parameters remained normal in patients who were hospitalized for SARS-CoV-2, persistently symptomatic, or with ongoing impaired exercise tolerance. Conclusion: Irrespective of ongoing symptoms or severity of prior illness, patients who have recovered from SARS-CoV-2 infection demonstrate normal functional and morphological cardiac parameters. Long-term cardiac changes due to SARS-CoV-2 infection appear to be rare. |
| format | Article |
| id | doaj-art-f9d0448eb0aa4eacb53d3183bc4865ba |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-f9d0448eb0aa4eacb53d3183bc4865ba2025-08-20T02:35:44ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-0126210112410.1016/j.jocmr.2024.101124Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up studyJanek Salatzki0Andreas Ochs1Lukas D. Weberling2Jannick Heins3Marc Zahlten4James G. Whayne5Christian Stehning6Evangelos Giannitsis7Claudia M. Denkinger8Uta Merle9Sebastian J. Buss10Henning Steen11Florian André12Norbert Frey13Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, Germany; Corresponding author. Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, Germany; Corresponding author. Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, GermanyMyocardial Solutions Inc., Morrisville, North Carolina, USAPhilips Clinical Science, Hamburg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, GermanyDivision of Infectious Disease and Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany; German Center of Infection Research, partner site Heidelberg, Heidelberg, GermanyDepartment of Gastroenterology, Infectious Diseases and Intoxication, University Hospital Heidelberg, Heidelberg, GermanyMVZ DRZ Heidelberg, Heidelberg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; medneo, Hamburg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Heidelberg, GermanyBackground: Concerns exist that long-term cardiac alterations occur after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, particularly in patients who were hospitalized in the acute phase or who remain symptomatic. This study investigates potential long-term functional and morphological alterations after SARS-CoV-2 infection. Methods: The authors of this study investigated patients after SARS-CoV-2 infection by using a mobile 1.5T clinical magnetic resonance scanner for cardiac alterations. Cardiac function and dimensions were assessed using a highly efficient cardiac magnetic resonance protocol, which included cine sequences, global longitudinal and circumferential strain assessed by fast-Strain-ENCoded imaging, and T1 and T2 mapping. We assessed symptoms through a questionnaire. Patients were compared with a control group matched for age, gender, body mass index, and body surface area. Results: Median follow-up time was 395 (192-408) days. The final population included 183 participants (age 48.4 ± 14.3 years, 48.1% male (88/183)). During the acute phase of SARS-CoV-2 infection, 27 patients were hospital-admitted. Forty-two patients reported persistent symptoms (shortness of breath, chest pain, palpitations, or leg edema), and 63 reported impaired exercise tolerance. Left ventricular (LV) functional and morphological parameters were within the normal range. T1- and T2-relaxation times were also within the normal range, indicating that the presence of myocardial edema or fibrosis was unlikely. Persistently symptomatic patients showed a slightly reduced indexed LV stroke volume. Functional parameters remained normal in patients who were hospitalized for SARS-CoV-2, persistently symptomatic, or with ongoing impaired exercise tolerance. Conclusion: Irrespective of ongoing symptoms or severity of prior illness, patients who have recovered from SARS-CoV-2 infection demonstrate normal functional and morphological cardiac parameters. Long-term cardiac changes due to SARS-CoV-2 infection appear to be rare.http://www.sciencedirect.com/science/article/pii/S1097664724011517CMRSARS-CoV-2COVIDFSENCCardiac impairmentPersistent symptom |
| spellingShingle | Janek Salatzki Andreas Ochs Lukas D. Weberling Jannick Heins Marc Zahlten James G. Whayne Christian Stehning Evangelos Giannitsis Claudia M. Denkinger Uta Merle Sebastian J. Buss Henning Steen Florian André Norbert Frey Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study Journal of Cardiovascular Magnetic Resonance CMR SARS-CoV-2 COVID FSENC Cardiac impairment Persistent symptom |
| title | Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study |
| title_full | Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study |
| title_fullStr | Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study |
| title_full_unstemmed | Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study |
| title_short | Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study |
| title_sort | absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection a long term follow up study |
| topic | CMR SARS-CoV-2 COVID FSENC Cardiac impairment Persistent symptom |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724011517 |
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