Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes
Objective. Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/8693516 |
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| author | Ping Gu Wei Wang Yue Yao Yixin Xu Liping Wang Pu Zang Jian Ma Cuihua Yang Junya Liang Bin Lu Jiaqing Shao |
| author_facet | Ping Gu Wei Wang Yue Yao Yixin Xu Liping Wang Pu Zang Jian Ma Cuihua Yang Junya Liang Bin Lu Jiaqing Shao |
| author_sort | Ping Gu |
| collection | DOAJ |
| description | Objective. Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. Methods. A total of 598 T2DM patients were classified into two groups: with and without microvascular complications. Anthropometric parameters and blood pressure were taken. The amounts of glycosylated hemoglobin, glucose, lipid profiles, creatinine, and chemerin concentrations in the blood were determined. The presence and severity of nephropathy, retinopathy, and neuropathy were also evaluated by specific tests. Results. Plasma levels of chemerin in diabetic subjects with microvascular complications were markedly elevated compared to those without. The number of microvascular complications increased with high plasma chemerin levels. Patients with high chemerin levels had an increased incidence of nephropathy and retinopathy. Furthermore, the chemerin plasma concentrations increased with the progression of diabetic nephropathy with highest values in macroalbuminuria groups. In contrast, no significant difference was observed in plasma chemerin levels between subjects with and without peripheral neuropathy. Pearson correlation analysis showed that plasma chemerin levels were positively related to duration of diabetes, serum creatinine, and 24-hour urine albumin excretion, even after multiple adjustments. Using logistic regression analysis, plasma chemerin concentrations were independently associated with the presence of nephropathy and retinopathy, not neuropathy. Conclusion. This study elucidated a positive correlation between increased chemerin levels and the development of some subtypes of diabetic microangiopathy. |
| format | Article |
| id | doaj-art-f9be7fd7f513428884bc5322135f57c4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f9be7fd7f513428884bc5322135f57c42025-02-03T05:51:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/86935168693516Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 DiabetesPing Gu0Wei Wang1Yue Yao2Yixin Xu3Liping Wang4Pu Zang5Jian Ma6Cuihua Yang7Junya Liang8Bin Lu9Jiaqing Shao10Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaHypertension Research Center, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, ChinaObjective. Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma chemerin levels and microangiopathy in patients with T2DM. Methods. A total of 598 T2DM patients were classified into two groups: with and without microvascular complications. Anthropometric parameters and blood pressure were taken. The amounts of glycosylated hemoglobin, glucose, lipid profiles, creatinine, and chemerin concentrations in the blood were determined. The presence and severity of nephropathy, retinopathy, and neuropathy were also evaluated by specific tests. Results. Plasma levels of chemerin in diabetic subjects with microvascular complications were markedly elevated compared to those without. The number of microvascular complications increased with high plasma chemerin levels. Patients with high chemerin levels had an increased incidence of nephropathy and retinopathy. Furthermore, the chemerin plasma concentrations increased with the progression of diabetic nephropathy with highest values in macroalbuminuria groups. In contrast, no significant difference was observed in plasma chemerin levels between subjects with and without peripheral neuropathy. Pearson correlation analysis showed that plasma chemerin levels were positively related to duration of diabetes, serum creatinine, and 24-hour urine albumin excretion, even after multiple adjustments. Using logistic regression analysis, plasma chemerin concentrations were independently associated with the presence of nephropathy and retinopathy, not neuropathy. Conclusion. This study elucidated a positive correlation between increased chemerin levels and the development of some subtypes of diabetic microangiopathy.http://dx.doi.org/10.1155/2019/8693516 |
| spellingShingle | Ping Gu Wei Wang Yue Yao Yixin Xu Liping Wang Pu Zang Jian Ma Cuihua Yang Junya Liang Bin Lu Jiaqing Shao Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes |
| title_full | Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes |
| title_fullStr | Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes |
| title_full_unstemmed | Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes |
| title_short | Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes |
| title_sort | increased circulating chemerin in relation to chronic microvascular complications in patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2019/8693516 |
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