Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study

Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study

Keratinocytes (KCs) from healthy donors stimulated with type 2 cytokines are often used to experimentally study atopic dermatitis (AD) inflammatory responses. Owing to potential intrinsic alterations, it seems favorable to use KCs from patients with AD. KCs isolated from hair follicles offer a nonin...

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Bibliographic Details
Main Authors: Hila Emmert, Franziska Rademacher, Matthias Hübenthal, Regine Gläser, Hanne Norsgaard, Stephan Weidinger, Jürgen Harder
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JID Innovations
Subjects:
3D skin models
Atopic dermatitis
Hair follicle–derived keratinocytes
IL-13
IL-4
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026724000560
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