Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy

Background and Objectives. Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. The objective of the current study was to evaluate...

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Main Authors: Seyit Uyar, Ayşe Balkarlı, Muhammet Kazım Erol, Bayram Yeşil, Abdullah Tokuç, Doğan Durmaz, Süheyla Görar, Ayhan Hilmi Çekin
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2016/7592402
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author Seyit Uyar
Ayşe Balkarlı
Muhammet Kazım Erol
Bayram Yeşil
Abdullah Tokuç
Doğan Durmaz
Süheyla Görar
Ayhan Hilmi Çekin
author_facet Seyit Uyar
Ayşe Balkarlı
Muhammet Kazım Erol
Bayram Yeşil
Abdullah Tokuç
Doğan Durmaz
Süheyla Görar
Ayhan Hilmi Çekin
author_sort Seyit Uyar
collection DOAJ
description Background and Objectives. Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. The objective of the current study was to evaluate nailfold capillaries in type 2 diabetes mellitus patients and to determine the association of retinopathy with changes in the nailfold capillaries. Materials and Methods. Capillaroscopic findings by nailfold capillaroscopy and fundoscopic examinations were assessed in 216 patients with type 2 diabetes mellitus and 101 healthy controls included in this prospective study. Results. Retinopathy was detected in 43.05% of diabetic patients (n=93). Capillaroscopic findings including tortuosity (p<0.001), bushy capillary (p<0.001), neoformation (p<0.001), bizarre capillary (p<0.001), microhemorrhage (p=0.001), capillary ectasia (p=0.002), and aneurysm (p=0.004) were significantly higher in diabetic group than control group. In logistic regression analysis, only tortuosity was shown significant (OR, 2.16; p=0.036). There was also a significant relation between diabetes duration and most of the capillaroscopic findings. Conclusion. Capillaroscopic changes were found to be correlated with diabetic retinopathy, in particular with longer disease duration in our study. Capillaroscopic imaging could be a useful new technique for assessment of diabetic microvascular changes.
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series Journal of Diabetes Research
spelling doaj-art-f9b89fb9a4eb43178542b16939a6f9e32025-02-03T01:02:50ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/75924027592402Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold VideocapillaroscopySeyit Uyar0Ayşe Balkarlı1Muhammet Kazım Erol2Bayram Yeşil3Abdullah Tokuç4Doğan Durmaz5Süheyla Görar6Ayhan Hilmi Çekin7University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Rheumatology, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Endocrinology, Antalya, TurkeyUniversity of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, TurkeyBackground and Objectives. Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. The objective of the current study was to evaluate nailfold capillaries in type 2 diabetes mellitus patients and to determine the association of retinopathy with changes in the nailfold capillaries. Materials and Methods. Capillaroscopic findings by nailfold capillaroscopy and fundoscopic examinations were assessed in 216 patients with type 2 diabetes mellitus and 101 healthy controls included in this prospective study. Results. Retinopathy was detected in 43.05% of diabetic patients (n=93). Capillaroscopic findings including tortuosity (p<0.001), bushy capillary (p<0.001), neoformation (p<0.001), bizarre capillary (p<0.001), microhemorrhage (p=0.001), capillary ectasia (p=0.002), and aneurysm (p=0.004) were significantly higher in diabetic group than control group. In logistic regression analysis, only tortuosity was shown significant (OR, 2.16; p=0.036). There was also a significant relation between diabetes duration and most of the capillaroscopic findings. Conclusion. Capillaroscopic changes were found to be correlated with diabetic retinopathy, in particular with longer disease duration in our study. Capillaroscopic imaging could be a useful new technique for assessment of diabetic microvascular changes.http://dx.doi.org/10.1155/2016/7592402
spellingShingle Seyit Uyar
Ayşe Balkarlı
Muhammet Kazım Erol
Bayram Yeşil
Abdullah Tokuç
Doğan Durmaz
Süheyla Görar
Ayhan Hilmi Çekin
Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
Journal of Diabetes Research
title Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
title_full Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
title_fullStr Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
title_full_unstemmed Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
title_short Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy
title_sort assessment of the relationship between diabetic retinopathy and nailfold capillaries in type 2 diabetics with a noninvasive method nailfold videocapillaroscopy
url http://dx.doi.org/10.1155/2016/7592402
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