Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal)
Abstract Background Three million babies die in the early neonatal period while 2.6 million are stillborn per year worldwide, and one of three deaths can be prevented. The perinatal mortality rate in Nepal is around 31 per 1000 births. Although the perinatal and neonatal death rates have decreased r...
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BMC
2025-02-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07240-9 |
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| author | Nuwadatta Subedi Sunita Ranabhat Sanjib Mani Regmi Mukesh Mallik Dela Singh Shree Krishna Shrestha Bandana Gurung Arjun Bhattarai Madan Prasad Baral Sudhir Raman Parajuli Ramchandra Bastola Junu Shrestha Sahisnuta Basnet Eva Gauchan Sabita Paudel |
| author_facet | Nuwadatta Subedi Sunita Ranabhat Sanjib Mani Regmi Mukesh Mallik Dela Singh Shree Krishna Shrestha Bandana Gurung Arjun Bhattarai Madan Prasad Baral Sudhir Raman Parajuli Ramchandra Bastola Junu Shrestha Sahisnuta Basnet Eva Gauchan Sabita Paudel |
| author_sort | Nuwadatta Subedi |
| collection | DOAJ |
| description | Abstract Background Three million babies die in the early neonatal period while 2.6 million are stillborn per year worldwide, and one of three deaths can be prevented. The perinatal mortality rate in Nepal is around 31 per 1000 births. Although the perinatal and neonatal death rates have decreased recently, it still poses a major challenge to the health system of Nepal. The objective of the study is to determine the causes of perinatal deaths by integrating Minimally Invasive Tissue Sampling (MITS) in hospital perinatal deaths and incorporating verbal autopsy in community deaths in Kaski district of Nepal. Methods The study will be conducted among the perinatal deaths reported in the five hospitals implementing the Maternal and Perinatal Death Surveillance and Response (MPDSR) system in Kaski district of Nepal. We will also conduct verbal autopsy (VA) among community perinatal deaths reported in the district. All the perinatal deaths reported in the study sites will be enrolled in the first stage of the study. Minimally Invasive Tissue Sampling (MITS) will be conducted among the consenting cases of perinatal deaths to retrieve relevant tissue samples and specimens. The specimens will undergo standard histopathological, microbiological, biochemical, and molecular tests. The “Cause of Death Panel” will finalize MITS informed cause of death following the customized protocol for the project and the cause so derived will be compared with that obtained by the review of deaths by the MPDSR committees of the hospitals. The Female Community Health Volunteers will be trained and mobilized to identify community perinatal deaths and trained personnel will conduct VA. Community engagement activities will be conducted to provide awareness to prevent perinatal deaths. Discussion The mechanism of counting and accounting for deaths in a systematic manner is important and it can provide evidence to determine changes in clinical practice and to develop guidelines and training packages for preventive measures. The outcome will be helpful to standardize methods to establish the accurate causes of perinatal deaths and develop strategies to minimize the deaths. The selected pathological investigations can be integrated into the existing death surveillance system in order to effectively determine the causes of death. |
| format | Article |
| id | doaj-art-f9b4b7760dfd4211ad683e0705b5316d |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-f9b4b7760dfd4211ad683e0705b5316d2025-02-09T12:58:59ZengBMCBMC Pregnancy and Childbirth1471-23932025-02-0125111110.1186/s12884-025-07240-9Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal)Nuwadatta Subedi0Sunita Ranabhat1Sanjib Mani Regmi2Mukesh Mallik3Dela Singh4Shree Krishna Shrestha5Bandana Gurung6Arjun Bhattarai7Madan Prasad Baral8Sudhir Raman Parajuli9Ramchandra Bastola10Junu Shrestha11Sahisnuta Basnet12Eva Gauchan13Sabita Paudel14Department of Forensic Medicine, Gandaki Medical College Teaching Hospital and Research CenterDepartment of Pathology, Gandaki Medical College Teaching Hospital and Research CenterDepartment of Microbiology, Pokhara Academy of Health SciencesPublic Health Expert and Social Scientist Perinatal MITS NepalDepartment of Obstetrics and Gynaecology, Pokhara Academy of Health SciencesDepartment of Pediatrics, Pokhara Academy of Health SciencesDepartment of Obstetrics and Gynaecology, Gandaki Medical College Teaching Hospital and Research CenterDepartment of Paediatrics, Gandaki Medical College Teaching Hospital and Research CenterDepartment of Forensic Medicine, Pokhara Academy of Health SciencesDepartment of Forensic Medicine, Manipal College of Medical SciencesDepartment of Pediatrics, Pokhara Academy of Health SciencesDepartment of Obstetrics and Gynaecology, Manipal College of Medical SciencesDepartment of Pediatrics, Manipal College of Medical SciencesDepartment of Pediatrics, Manipal College of Medical SciencesDepartment of Pharmacology, Gandaki Medical College Teaching Hospital and Research CenterAbstract Background Three million babies die in the early neonatal period while 2.6 million are stillborn per year worldwide, and one of three deaths can be prevented. The perinatal mortality rate in Nepal is around 31 per 1000 births. Although the perinatal and neonatal death rates have decreased recently, it still poses a major challenge to the health system of Nepal. The objective of the study is to determine the causes of perinatal deaths by integrating Minimally Invasive Tissue Sampling (MITS) in hospital perinatal deaths and incorporating verbal autopsy in community deaths in Kaski district of Nepal. Methods The study will be conducted among the perinatal deaths reported in the five hospitals implementing the Maternal and Perinatal Death Surveillance and Response (MPDSR) system in Kaski district of Nepal. We will also conduct verbal autopsy (VA) among community perinatal deaths reported in the district. All the perinatal deaths reported in the study sites will be enrolled in the first stage of the study. Minimally Invasive Tissue Sampling (MITS) will be conducted among the consenting cases of perinatal deaths to retrieve relevant tissue samples and specimens. The specimens will undergo standard histopathological, microbiological, biochemical, and molecular tests. The “Cause of Death Panel” will finalize MITS informed cause of death following the customized protocol for the project and the cause so derived will be compared with that obtained by the review of deaths by the MPDSR committees of the hospitals. The Female Community Health Volunteers will be trained and mobilized to identify community perinatal deaths and trained personnel will conduct VA. Community engagement activities will be conducted to provide awareness to prevent perinatal deaths. Discussion The mechanism of counting and accounting for deaths in a systematic manner is important and it can provide evidence to determine changes in clinical practice and to develop guidelines and training packages for preventive measures. The outcome will be helpful to standardize methods to establish the accurate causes of perinatal deaths and develop strategies to minimize the deaths. The selected pathological investigations can be integrated into the existing death surveillance system in order to effectively determine the causes of death.https://doi.org/10.1186/s12884-025-07240-9Cause of deathDeath surveillance systemMinimally invasive tissue samplingStillbirthPerinatal deathsVerbal autopsy |
| spellingShingle | Nuwadatta Subedi Sunita Ranabhat Sanjib Mani Regmi Mukesh Mallik Dela Singh Shree Krishna Shrestha Bandana Gurung Arjun Bhattarai Madan Prasad Baral Sudhir Raman Parajuli Ramchandra Bastola Junu Shrestha Sahisnuta Basnet Eva Gauchan Sabita Paudel Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) BMC Pregnancy and Childbirth Cause of death Death surveillance system Minimally invasive tissue sampling Stillbirth Perinatal deaths Verbal autopsy |
| title | Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) |
| title_full | Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) |
| title_fullStr | Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) |
| title_full_unstemmed | Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) |
| title_short | Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) |
| title_sort | strengthening identification and characterization of causes of perinatal deaths in kaski district of nepal perinatal mits nepal |
| topic | Cause of death Death surveillance system Minimally invasive tissue sampling Stillbirth Perinatal deaths Verbal autopsy |
| url | https://doi.org/10.1186/s12884-025-07240-9 |
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