External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder?
Neuroendocrine tumors commonly involve the respiratory and gastrointestinal systems. Primary genitourinary neuroendocrine tumors are rare, accounting for less than 1% of all bladder carcinomas. Four histopathologic subtypes have been described. Among those, large cell neuroendocrine carcinoma (LCNEC...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/1853985 |
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| author | Ali Zakaria Bayan Al Share Sri Kollepara Cynthia Vakhariya |
| author_facet | Ali Zakaria Bayan Al Share Sri Kollepara Cynthia Vakhariya |
| author_sort | Ali Zakaria |
| collection | DOAJ |
| description | Neuroendocrine tumors commonly involve the respiratory and gastrointestinal systems. Primary genitourinary neuroendocrine tumors are rare, accounting for less than 1% of all bladder carcinomas. Four histopathologic subtypes have been described. Among those, large cell neuroendocrine carcinoma (LCNEC) is the least common, is more aggressive, and generally presents in an advanced stage with poor prognosis compared to transitional cell bladder carcinoma. There is no standardized treatment regimen because of the rarity of the disease. Herein, we present a case of 72-year-old male patient with previously treated prostate cancer, who received external beam radiation therapy and high dose brachytherapy, presenting with intermittent hematuria. Cystoscopy and transurethral resection of bladder tumor (TURBT) were performed. The histopathology and immunohistochemistry were consistent with large cell neuroendocrine carcinoma (LCNEC). Further studies are required to proof the higher risk of neuroendocrine carcinoma of the bladder in patients treated with external beam radiation therapy and brachytherapy for prostate cancer. |
| format | Article |
| id | doaj-art-f9ad3b3d6c17491f904e52916257b05d |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-f9ad3b3d6c17491f904e52916257b05d2025-02-03T01:08:50ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/18539851853985External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder?Ali Zakaria0Bayan Al Share1Sri Kollepara2Cynthia Vakhariya3Department of Internal Medicine, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI, USADepartment of Internal Medicine, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI, USADivision of Hematology & Oncology, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI, USADivision of Hematology & Oncology, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI, USANeuroendocrine tumors commonly involve the respiratory and gastrointestinal systems. Primary genitourinary neuroendocrine tumors are rare, accounting for less than 1% of all bladder carcinomas. Four histopathologic subtypes have been described. Among those, large cell neuroendocrine carcinoma (LCNEC) is the least common, is more aggressive, and generally presents in an advanced stage with poor prognosis compared to transitional cell bladder carcinoma. There is no standardized treatment regimen because of the rarity of the disease. Herein, we present a case of 72-year-old male patient with previously treated prostate cancer, who received external beam radiation therapy and high dose brachytherapy, presenting with intermittent hematuria. Cystoscopy and transurethral resection of bladder tumor (TURBT) were performed. The histopathology and immunohistochemistry were consistent with large cell neuroendocrine carcinoma (LCNEC). Further studies are required to proof the higher risk of neuroendocrine carcinoma of the bladder in patients treated with external beam radiation therapy and brachytherapy for prostate cancer.http://dx.doi.org/10.1155/2017/1853985 |
| spellingShingle | Ali Zakaria Bayan Al Share Sri Kollepara Cynthia Vakhariya External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? Case Reports in Oncological Medicine |
| title | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? |
| title_full | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? |
| title_fullStr | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? |
| title_full_unstemmed | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? |
| title_short | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? |
| title_sort | external beam radiation and brachytherapy for prostate cancer is it a possible trigger of large cell neuroendocrine carcinoma of the urinary bladder |
| url | http://dx.doi.org/10.1155/2017/1853985 |
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