Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats
Background: Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties. Aim: This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma z...
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| Format: | Article |
| Language: | English |
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Tripoli University
2025-01-01
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| Series: | Open Veterinary Journal |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=225425 |
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| author | Putri Reno Intan Sukmayati Alegantina Hidayatul Fajri Fitrine Ekawasti Ani Isnawati Lisa Andriani Lienggonegoro Uly Alfi Nikmah Sunarno Sunarno Sela Septima Mariya Lina Noviyanti Sutardi Agus Setiyono Ekowati Handharyani |
| author_facet | Putri Reno Intan Sukmayati Alegantina Hidayatul Fajri Fitrine Ekawasti Ani Isnawati Lisa Andriani Lienggonegoro Uly Alfi Nikmah Sunarno Sunarno Sela Septima Mariya Lina Noviyanti Sutardi Agus Setiyono Ekowati Handharyani |
| author_sort | Putri Reno Intan |
| collection | DOAJ |
| description | Background:
Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties.
Aim:
This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on TNF-α, KIM-1, and Caspase-3 levels.
Methods:
Twenty-five rats were divided into normal control groups (NS), cisplatin control groups (CIS), and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively on day 1-20. All groups, except the NS group (receiving normal saline i. p.), received intraperitoneal cisplatin (1 mg/kg) on days 7 and 14 of the 20-day extract treatment.
Results:
Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, dexertedthe most apparent protective effect, decreasing renal TNF-α, KIM-1,, and caspase 3.
Conclusion:
The combined extract of Curcuma longa and Curcuma zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans. [Open Vet J 2025; 15(1.000): 428-436] |
| format | Article |
| id | doaj-art-f9abe4e9cda0492fbbc4e451150db390 |
| institution | OA Journals |
| issn | 2226-4485 2218-6050 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj-art-f9abe4e9cda0492fbbc4e451150db3902025-08-20T02:16:05ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502025-01-0115142843610.5455/OVJ.2025.v15.i1.38225425Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in ratsPutri Reno Intan0Sukmayati Alegantina1Hidayatul Fajri2Fitrine Ekawasti3Ani Isnawati4Lisa Andriani Lienggonegoro5Uly Alfi Nikmah6Sunarno Sunarno7Sela Septima Mariya8Lina Noviyanti Sutardi9Agus Setiyono10Ekowati Handharyani111. Animal Biomedical Study Program, IPB Postgraduate School, School of Veterinary Medicine and Biomedicine, IPB University, Bogor, 16680, Indonesia. 2. Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia 1. Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia. 2. 4 Department of Biology, Faculty of Biology and Agriculture, Universitas Nasional, Jakarta, Indonesia, 12520, Indonesia Research Centre for Veterinary Science, Research Organization for Health, National Research and Innovation Agency, Cibinong, West Java, 16911, Indonesia Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, Indonesia Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong - Bogor, West Java, 16911, Indonesia Division of Pharmacy, School of Veterinary Medicine and Biomedicine, IPB University, 16680, Indonesia Division of Pathology, School of Veterinary Medicine and Biomedicine, IPB University, 16680, Indonesia Division of Pathology, School of Veterinary Medicine and Biomedicine, IPB University, 16680, IndonesiaBackground: Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties. Aim: This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on TNF-α, KIM-1, and Caspase-3 levels. Methods: Twenty-five rats were divided into normal control groups (NS), cisplatin control groups (CIS), and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively on day 1-20. All groups, except the NS group (receiving normal saline i. p.), received intraperitoneal cisplatin (1 mg/kg) on days 7 and 14 of the 20-day extract treatment. Results: Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, dexertedthe most apparent protective effect, decreasing renal TNF-α, KIM-1,, and caspase 3. Conclusion: The combined extract of Curcuma longa and Curcuma zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans. [Open Vet J 2025; 15(1.000): 428-436]http://www.ejmanager.com/fulltextpdf.php?mno=225425cisplatincurcuma longacurcuma zedoariainflammationnephrotoxicity |
| spellingShingle | Putri Reno Intan Sukmayati Alegantina Hidayatul Fajri Fitrine Ekawasti Ani Isnawati Lisa Andriani Lienggonegoro Uly Alfi Nikmah Sunarno Sunarno Sela Septima Mariya Lina Noviyanti Sutardi Agus Setiyono Ekowati Handharyani Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats Open Veterinary Journal cisplatin curcuma longa curcuma zedoaria inflammation nephrotoxicity |
| title | Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats |
| title_full | Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats |
| title_fullStr | Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats |
| title_full_unstemmed | Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats |
| title_short | Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats |
| title_sort | combined extracts of curcuma longa and curcuma zedoaria ameliorates cisplatin induced kidney damage in rats |
| topic | cisplatin curcuma longa curcuma zedoaria inflammation nephrotoxicity |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=225425 |
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