Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats
Background: Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties. Aim: This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma z...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2025-01-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=225425 |
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| Summary: | Background:
Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties.
Aim:
This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on TNF-α, KIM-1, and Caspase-3 levels.
Methods:
Twenty-five rats were divided into normal control groups (NS), cisplatin control groups (CIS), and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively on day 1-20. All groups, except the NS group (receiving normal saline i. p.), received intraperitoneal cisplatin (1 mg/kg) on days 7 and 14 of the 20-day extract treatment.
Results:
Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, dexertedthe most apparent protective effect, decreasing renal TNF-α, KIM-1,, and caspase 3.
Conclusion:
The combined extract of Curcuma longa and Curcuma zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans. [Open Vet J 2025; 15(1.000): 428-436] |
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| ISSN: | 2226-4485 2218-6050 |