Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy

The aim of publication. To present a case of sarcoid-like reaction development, induced by antiviral therapy, in patient with chronic hepatitis C, as well as the management approach for this patient.Features of clinical case. At female 53 year-old patient with chronic hepatitis C (HCV RNA+, genotype...

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Main Authors: A. V. Lapshin, N. I. Kokina, M. V. Mayevskaya, I. A. Sokolina, V. T. Ivashkin
Format: Article
Language:Russian
Published: Gastro LLC 2010-06-01
Series:Российский журнал гастроэнтерологии, гепатологии, колопроктологии
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Online Access:https://www.gastro-j.ru/jour/article/view/1528
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author A. V. Lapshin
N. I. Kokina
M. V. Mayevskaya
I. A. Sokolina
V. T. Ivashkin
author_facet A. V. Lapshin
N. I. Kokina
M. V. Mayevskaya
I. A. Sokolina
V. T. Ivashkin
author_sort A. V. Lapshin
collection DOAJ
description The aim of publication. To present a case of sarcoid-like reaction development, induced by antiviral therapy, in patient with chronic hepatitis C, as well as the management approach for this patient.Features of clinical case. At female 53 year-old patient with chronic hepatitis C (HCV RNA+, genotype 1b) of moderate activity (А2, F0 by METAVIR scale) development of granulomatous pulmonary lesion accompanied by fever, respiratory failure, asthenic syndrome had been observed on the 22-nd week of antiviral therapy by PEG-interferon and ribavirin. Sarcoid-like reaction has been diagnosed. At computer tomography of the chest organs bilateral miliary monomorphic dissimination on a background of interstitial changes was found, intrathoracic lymph nodes were increased in their number and size. Cessation of antiviral therapy did not result in improvement of patient’s state within 2 months. Immune-suppressive therapy by methylprednisolon and phosphogliv was prescribed, that resulted in complete regression of clinical symptoms and radiological changes in the lungs. Sustained virologic response was preserved in the patient.Conclusion. Sarcoid-like reaction falls to rare unpredictable complications of antiviral therapy. Expected side effects of antiviral therapy can mask development of sarcoid-like reaction.
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series Российский журнал гастроэнтерологии, гепатологии, колопроктологии
spelling doaj-art-f99aa7f94c0143af972fdd6edd13c0e02025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-06-0120374781045Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapyA. V. LapshinN. I. KokinaM. V. MayevskayaI. A. SokolinaV. T. IvashkinThe aim of publication. To present a case of sarcoid-like reaction development, induced by antiviral therapy, in patient with chronic hepatitis C, as well as the management approach for this patient.Features of clinical case. At female 53 year-old patient with chronic hepatitis C (HCV RNA+, genotype 1b) of moderate activity (А2, F0 by METAVIR scale) development of granulomatous pulmonary lesion accompanied by fever, respiratory failure, asthenic syndrome had been observed on the 22-nd week of antiviral therapy by PEG-interferon and ribavirin. Sarcoid-like reaction has been diagnosed. At computer tomography of the chest organs bilateral miliary monomorphic dissimination on a background of interstitial changes was found, intrathoracic lymph nodes were increased in their number and size. Cessation of antiviral therapy did not result in improvement of patient’s state within 2 months. Immune-suppressive therapy by methylprednisolon and phosphogliv was prescribed, that resulted in complete regression of clinical symptoms and radiological changes in the lungs. Sustained virologic response was preserved in the patient.Conclusion. Sarcoid-like reaction falls to rare unpredictable complications of antiviral therapy. Expected side effects of antiviral therapy can mask development of sarcoid-like reaction.https://www.gastro-j.ru/jour/article/view/1528sarcoid-like reactioninterferonhepatitis c
spellingShingle A. V. Lapshin
N. I. Kokina
M. V. Mayevskaya
I. A. Sokolina
V. T. Ivashkin
Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
Российский журнал гастроэнтерологии, гепатологии, колопроктологии
sarcoid-like reaction
interferon
hepatitis c
title Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
title_full Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
title_fullStr Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
title_full_unstemmed Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
title_short Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy
title_sort sarcoid like reaction at the patient with chronic hepatitis c on a background of antiviral therapy
topic sarcoid-like reaction
interferon
hepatitis c
url https://www.gastro-j.ru/jour/article/view/1528
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AT nikokina sarcoidlikereactionatthepatientwithchronichepatitisconabackgroundofantiviraltherapy
AT mvmayevskaya sarcoidlikereactionatthepatientwithchronichepatitisconabackgroundofantiviraltherapy
AT iasokolina sarcoidlikereactionatthepatientwithchronichepatitisconabackgroundofantiviraltherapy
AT vtivashkin sarcoidlikereactionatthepatientwithchronichepatitisconabackgroundofantiviraltherapy