Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based app...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2012/350853 |
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| author | Olusegun J. Ilegbusi Zhiliang Li Behnaz Seyfi Yugang Min Sanford Meeks Patrick Kupelian Anand P. Santhanam |
| author_facet | Olusegun J. Ilegbusi Zhiliang Li Behnaz Seyfi Yugang Min Sanford Meeks Patrick Kupelian Anand P. Santhanam |
| author_sort | Olusegun J. Ilegbusi |
| collection | DOAJ |
| description | Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis. |
| format | Article |
| id | doaj-art-f96ddf25acf44cdd85c2a5c1f6a7df10 |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-f96ddf25acf44cdd85c2a5c1f6a7df102025-02-03T05:46:46ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/350853350853Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung ModelsOlusegun J. Ilegbusi0Zhiliang Li1Behnaz Seyfi2Yugang Min3Sanford Meeks4Patrick Kupelian5Anand P. Santhanam6Department of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USADepartment of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, FL 32806 , USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USALung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.http://dx.doi.org/10.1155/2012/350853 |
| spellingShingle | Olusegun J. Ilegbusi Zhiliang Li Behnaz Seyfi Yugang Min Sanford Meeks Patrick Kupelian Anand P. Santhanam Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models International Journal of Biomedical Imaging |
| title | Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models |
| title_full | Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models |
| title_fullStr | Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models |
| title_full_unstemmed | Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models |
| title_short | Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models |
| title_sort | modeling airflow using subject specific 4dct based deformable volumetric lung models |
| url | http://dx.doi.org/10.1155/2012/350853 |
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