The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series
Ofatumumab (OFA) is an anti-CD20 antibody. We assessed the therapeutic potential of OFA in five pediatric anti-NMDAR encephalitis patients who showed poor responses to the first-line immunotherapy. OFA treatment showed clinical improvement including alleviation of clinical symptoms and mRS decrease...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024167114 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850245205819654144 |
|---|---|
| author | Wenlin Wu Jie Hong Yanping Ran Wenxiao Wu Haixia Zhu Chi Hou Yuanyuan Gao Yulin Tang Yinting Liao Wen-Xiong Chen Xiaojing Li |
| author_facet | Wenlin Wu Jie Hong Yanping Ran Wenxiao Wu Haixia Zhu Chi Hou Yuanyuan Gao Yulin Tang Yinting Liao Wen-Xiong Chen Xiaojing Li |
| author_sort | Wenlin Wu |
| collection | DOAJ |
| description | Ofatumumab (OFA) is an anti-CD20 antibody. We assessed the therapeutic potential of OFA in five pediatric anti-NMDAR encephalitis patients who showed poor responses to the first-line immunotherapy. OFA treatment showed clinical improvement including alleviation of clinical symptoms and mRS decrease accompanied by anti-NMDAR antibody turning negative in 3 patients and decline in 2 patients. And all patients achieved B cell depletion after OFA treatment. During follow-up, all patients’ symptoms were stable. OFA treatment is safe and effective, easy to administer, and favorable for pediatric anti-NMDAE encephalitis patients who are refractory to the first-line immunotherapy. |
| format | Article |
| id | doaj-art-f95d2e96d1cc4894aaa2b32ddc59fdd9 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-f95d2e96d1cc4894aaa2b32ddc59fdd92025-08-20T01:59:31ZengElsevierHeliyon2405-84402024-12-011023e4068010.1016/j.heliyon.2024.e40680The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case seriesWenlin Wu0Jie Hong1Yanping Ran2Wenxiao Wu3Haixia Zhu4Chi Hou5Yuanyuan Gao6Yulin Tang7Yinting Liao8Wen-Xiong Chen9Xiaojing Li10Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaDepartment of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaCorresponding author. Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City No.9, Jinsui Road, Tianhe District, Guangzhou City, 510623, Guangdong Province, China.; Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaCorresponding author. Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, No.9, Jinsui Road, Tianhe District, Guangzhou City, 510623, Guangdong Province, China.; Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, ChinaOfatumumab (OFA) is an anti-CD20 antibody. We assessed the therapeutic potential of OFA in five pediatric anti-NMDAR encephalitis patients who showed poor responses to the first-line immunotherapy. OFA treatment showed clinical improvement including alleviation of clinical symptoms and mRS decrease accompanied by anti-NMDAR antibody turning negative in 3 patients and decline in 2 patients. And all patients achieved B cell depletion after OFA treatment. During follow-up, all patients’ symptoms were stable. OFA treatment is safe and effective, easy to administer, and favorable for pediatric anti-NMDAE encephalitis patients who are refractory to the first-line immunotherapy.http://www.sciencedirect.com/science/article/pii/S2405844024167114RefractoryAnti-NMDAR encephalitisChildrenOfatumumab |
| spellingShingle | Wenlin Wu Jie Hong Yanping Ran Wenxiao Wu Haixia Zhu Chi Hou Yuanyuan Gao Yulin Tang Yinting Liao Wen-Xiong Chen Xiaojing Li The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series Heliyon Refractory Anti-NMDAR encephalitis Children Ofatumumab |
| title | The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series |
| title_full | The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series |
| title_fullStr | The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series |
| title_full_unstemmed | The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series |
| title_short | The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series |
| title_sort | therapeutic effect of ofatumumab in pediatric anti nmdar encephalitis a case series |
| topic | Refractory Anti-NMDAR encephalitis Children Ofatumumab |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024167114 |
| work_keys_str_mv | AT wenlinwu thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT jiehong thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yanpingran thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT wenxiaowu thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT haixiazhu thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT chihou thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yuanyuangao thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yulintang thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yintingliao thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT wenxiongchen thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT xiaojingli thetherapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT wenlinwu therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT jiehong therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yanpingran therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT wenxiaowu therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT haixiazhu therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT chihou therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yuanyuangao therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yulintang therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT yintingliao therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT wenxiongchen therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries AT xiaojingli therapeuticeffectofofatumumabinpediatricantinmdarencephalitisacaseseries |