Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donor...
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Elsevier
2025-03-01
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Series: | EClinicalMedicine |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537025000276 |
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author | Michael X. Fu Ahmed Elsharkawy Brendan Healy Celia Jackson Daniel Bradshaw Emma Watkins Ines Ushiro-Lumb Jaisi Griffiths James Neuberger Kathryn Maguire Monica Desai Neil McDougall Nicole Priddee Stephen T. Barclay Stuart Blackmore Peter Simmonds William L. Irving Heli Harvala |
author_facet | Michael X. Fu Ahmed Elsharkawy Brendan Healy Celia Jackson Daniel Bradshaw Emma Watkins Ines Ushiro-Lumb Jaisi Griffiths James Neuberger Kathryn Maguire Monica Desai Neil McDougall Nicole Priddee Stephen T. Barclay Stuart Blackmore Peter Simmonds William L. Irving Heli Harvala |
author_sort | Michael X. Fu |
collection | DOAJ |
description | Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donors with occult HBV infection (OBI) is a complex dilemma involving virological, clinical, methodological, and social issues. Limited evidence suggests that OBI may accelerate the progression of liver disease and cancer. The need for a specialist referral for donors identified with OBI carries mixed opinions from blood establishments, hepatologists, and public health. Following extensive multidisciplinary discussions, experts agree upon a need for clear messaging for donors and to consider the oncogenic implications of OBI. Proposals for future studies are identified, and the applicability of the recommendations in low-resource, high-endemic regions is considered, as well as the inclusion of OBI in global hepatitis elimination targets. |
format | Article |
id | doaj-art-f953b3ceef3342749f08467b3a31ac27 |
institution | Kabale University |
issn | 2589-5370 |
language | English |
publishDate | 2025-03-01 |
publisher | Elsevier |
record_format | Article |
series | EClinicalMedicine |
spelling | doaj-art-f953b3ceef3342749f08467b3a31ac272025-02-02T05:29:11ZengElsevierEClinicalMedicine2589-53702025-03-0181103095Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?Michael X. Fu0Ahmed Elsharkawy1Brendan Healy2Celia Jackson3Daniel Bradshaw4Emma Watkins5Ines Ushiro-Lumb6Jaisi Griffiths7James Neuberger8Kathryn Maguire9Monica Desai10Neil McDougall11Nicole Priddee12Stephen T. Barclay13Stuart Blackmore14Peter Simmonds15William L. Irving16Heli Harvala17Nuffield Department of Medicine, University of Oxford, Oxford, UKLiver Unit, Queen Elizabeth Hospital Birmingham, NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham, Birmingham, UKPublic Health Wales and Swansea Bay University Health Board, Swansea, UKWest of Scotland Specialist Virology Centre, Glasgow, UKVirus Reference Department, UK Health Security Agency, London, UKClinical Services, NHS Blood and Transplant, Birmingham, UKMicrobiology Services, NHS Blood and Transplant, Colindale, UKWales Specialist Virology Centre, Cardiff, UKLiver Unit, Queen Elizabeth Hospital Birmingham, NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham, Birmingham, UKNorthern Ireland Blood Transfusion Service, Belfast, UKBlood Safety, UK Health Security Agency, London, UKThe Liver Unit, Royal Victoria Hospital, Belfast, UKDonor Services Division, Scottish National Blood Transfusion Service, Edinburgh, UKDepartment of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UKWelsh Blood Service, Pontyclun, UKNuffield Department of Medicine, University of Oxford, Oxford, UKNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UKMicrobiology Services, NHS Blood and Transplant, Colindale, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Corresponding author. Microbiology Services, NHS Blood and Transplant, Colindale, UK.Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donors with occult HBV infection (OBI) is a complex dilemma involving virological, clinical, methodological, and social issues. Limited evidence suggests that OBI may accelerate the progression of liver disease and cancer. The need for a specialist referral for donors identified with OBI carries mixed opinions from blood establishments, hepatologists, and public health. Following extensive multidisciplinary discussions, experts agree upon a need for clear messaging for donors and to consider the oncogenic implications of OBI. Proposals for future studies are identified, and the applicability of the recommendations in low-resource, high-endemic regions is considered, as well as the inclusion of OBI in global hepatitis elimination targets.http://www.sciencedirect.com/science/article/pii/S2589537025000276Hepatitis BBlood donorsLiver diseasesReferral and consultationConsensus |
spellingShingle | Michael X. Fu Ahmed Elsharkawy Brendan Healy Celia Jackson Daniel Bradshaw Emma Watkins Ines Ushiro-Lumb Jaisi Griffiths James Neuberger Kathryn Maguire Monica Desai Neil McDougall Nicole Priddee Stephen T. Barclay Stuart Blackmore Peter Simmonds William L. Irving Heli Harvala Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? EClinicalMedicine Hepatitis B Blood donors Liver diseases Referral and consultation Consensus |
title | Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? |
title_full | Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? |
title_fullStr | Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? |
title_full_unstemmed | Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? |
title_short | Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health? |
title_sort | occult hepatitis b virus infection risk for a blood supply but how about individuals health |
topic | Hepatitis B Blood donors Liver diseases Referral and consultation Consensus |
url | http://www.sciencedirect.com/science/article/pii/S2589537025000276 |
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