Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?

Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donor...

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Main Authors: Michael X. Fu, Ahmed Elsharkawy, Brendan Healy, Celia Jackson, Daniel Bradshaw, Emma Watkins, Ines Ushiro-Lumb, Jaisi Griffiths, James Neuberger, Kathryn Maguire, Monica Desai, Neil McDougall, Nicole Priddee, Stephen T. Barclay, Stuart Blackmore, Peter Simmonds, William L. Irving, Heli Harvala
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EClinicalMedicine
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025000276
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author Michael X. Fu
Ahmed Elsharkawy
Brendan Healy
Celia Jackson
Daniel Bradshaw
Emma Watkins
Ines Ushiro-Lumb
Jaisi Griffiths
James Neuberger
Kathryn Maguire
Monica Desai
Neil McDougall
Nicole Priddee
Stephen T. Barclay
Stuart Blackmore
Peter Simmonds
William L. Irving
Heli Harvala
author_facet Michael X. Fu
Ahmed Elsharkawy
Brendan Healy
Celia Jackson
Daniel Bradshaw
Emma Watkins
Ines Ushiro-Lumb
Jaisi Griffiths
James Neuberger
Kathryn Maguire
Monica Desai
Neil McDougall
Nicole Priddee
Stephen T. Barclay
Stuart Blackmore
Peter Simmonds
William L. Irving
Heli Harvala
author_sort Michael X. Fu
collection DOAJ
description Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donors with occult HBV infection (OBI) is a complex dilemma involving virological, clinical, methodological, and social issues. Limited evidence suggests that OBI may accelerate the progression of liver disease and cancer. The need for a specialist referral for donors identified with OBI carries mixed opinions from blood establishments, hepatologists, and public health. Following extensive multidisciplinary discussions, experts agree upon a need for clear messaging for donors and to consider the oncogenic implications of OBI. Proposals for future studies are identified, and the applicability of the recommendations in low-resource, high-endemic regions is considered, as well as the inclusion of OBI in global hepatitis elimination targets.
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issn 2589-5370
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publisher Elsevier
record_format Article
series EClinicalMedicine
spelling doaj-art-f953b3ceef3342749f08467b3a31ac272025-02-02T05:29:11ZengElsevierEClinicalMedicine2589-53702025-03-0181103095Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?Michael X. Fu0Ahmed Elsharkawy1Brendan Healy2Celia Jackson3Daniel Bradshaw4Emma Watkins5Ines Ushiro-Lumb6Jaisi Griffiths7James Neuberger8Kathryn Maguire9Monica Desai10Neil McDougall11Nicole Priddee12Stephen T. Barclay13Stuart Blackmore14Peter Simmonds15William L. Irving16Heli Harvala17Nuffield Department of Medicine, University of Oxford, Oxford, UKLiver Unit, Queen Elizabeth Hospital Birmingham, NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham, Birmingham, UKPublic Health Wales and Swansea Bay University Health Board, Swansea, UKWest of Scotland Specialist Virology Centre, Glasgow, UKVirus Reference Department, UK Health Security Agency, London, UKClinical Services, NHS Blood and Transplant, Birmingham, UKMicrobiology Services, NHS Blood and Transplant, Colindale, UKWales Specialist Virology Centre, Cardiff, UKLiver Unit, Queen Elizabeth Hospital Birmingham, NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham, Birmingham, UKNorthern Ireland Blood Transfusion Service, Belfast, UKBlood Safety, UK Health Security Agency, London, UKThe Liver Unit, Royal Victoria Hospital, Belfast, UKDonor Services Division, Scottish National Blood Transfusion Service, Edinburgh, UKDepartment of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UKWelsh Blood Service, Pontyclun, UKNuffield Department of Medicine, University of Oxford, Oxford, UKNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UKMicrobiology Services, NHS Blood and Transplant, Colindale, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Corresponding author. Microbiology Services, NHS Blood and Transplant, Colindale, UK.Summary: The implementation of effective blood donation screening for hepatitis B virus (HBV) anti-core antibodies with highly sensitive molecular HBV DNA detection in low-endemic countries like the United Kingdom has improved blood safety. However, the linkage to care and management for blood donors with occult HBV infection (OBI) is a complex dilemma involving virological, clinical, methodological, and social issues. Limited evidence suggests that OBI may accelerate the progression of liver disease and cancer. The need for a specialist referral for donors identified with OBI carries mixed opinions from blood establishments, hepatologists, and public health. Following extensive multidisciplinary discussions, experts agree upon a need for clear messaging for donors and to consider the oncogenic implications of OBI. Proposals for future studies are identified, and the applicability of the recommendations in low-resource, high-endemic regions is considered, as well as the inclusion of OBI in global hepatitis elimination targets.http://www.sciencedirect.com/science/article/pii/S2589537025000276Hepatitis BBlood donorsLiver diseasesReferral and consultationConsensus
spellingShingle Michael X. Fu
Ahmed Elsharkawy
Brendan Healy
Celia Jackson
Daniel Bradshaw
Emma Watkins
Ines Ushiro-Lumb
Jaisi Griffiths
James Neuberger
Kathryn Maguire
Monica Desai
Neil McDougall
Nicole Priddee
Stephen T. Barclay
Stuart Blackmore
Peter Simmonds
William L. Irving
Heli Harvala
Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
EClinicalMedicine
Hepatitis B
Blood donors
Liver diseases
Referral and consultation
Consensus
title Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
title_full Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
title_fullStr Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
title_full_unstemmed Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
title_short Occult hepatitis B virus infection: risk for a blood supply, but how about individuals’ health?
title_sort occult hepatitis b virus infection risk for a blood supply but how about individuals health
topic Hepatitis B
Blood donors
Liver diseases
Referral and consultation
Consensus
url http://www.sciencedirect.com/science/article/pii/S2589537025000276
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