Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response
Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as a crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence of gut microbiota on tumor immune surveillance and responses to immunotherapie...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1557959/full |
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| author | Chunlei Zhang Yong Wang Lei Cheng Xiansheng Cao Chunyuan Liu |
| author_facet | Chunlei Zhang Yong Wang Lei Cheng Xiansheng Cao Chunyuan Liu |
| author_sort | Chunlei Zhang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as a crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence of gut microbiota on tumor immune surveillance and responses to immunotherapies and chemotherapy in CRC. We highlight the role of specific microbial taxa in promoting or inhibiting tumor growth and the potential of microbiota-based biomarkers for predicting treatment efficacy. The review also discusses the implications of microbiota modulation strategies, including diet, probiotics, and fecal microbiota transplantation, for personalized CRC management. By critically evaluating the literature, we aim to provide a comprehensive understanding of the gut microbiota’s dual role in CRC and to inform future research directions in this field. |
| format | Article |
| id | doaj-art-f9474514f5ce4ac8bf3db5fa8fbd271e |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-f9474514f5ce4ac8bf3db5fa8fbd271e2025-08-20T02:03:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15579591557959Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic responseChunlei Zhang0Yong Wang1Lei Cheng2Xiansheng Cao3Chunyuan Liu4Department of Colorectal and Anus Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Hepatobiliary Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Colorectal and Anus Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Gastrointestinal Surgery, Hernia and Abdominal Wall Surgery I, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Colorectal and Anus Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaColorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as a crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence of gut microbiota on tumor immune surveillance and responses to immunotherapies and chemotherapy in CRC. We highlight the role of specific microbial taxa in promoting or inhibiting tumor growth and the potential of microbiota-based biomarkers for predicting treatment efficacy. The review also discusses the implications of microbiota modulation strategies, including diet, probiotics, and fecal microbiota transplantation, for personalized CRC management. By critically evaluating the literature, we aim to provide a comprehensive understanding of the gut microbiota’s dual role in CRC and to inform future research directions in this field.https://www.frontiersin.org/articles/10.3389/fonc.2025.1557959/fullcolorectal cancergut microbiotatumor immune surveillancetherapeutic responseprobioticsprebiotics |
| spellingShingle | Chunlei Zhang Yong Wang Lei Cheng Xiansheng Cao Chunyuan Liu Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response Frontiers in Oncology colorectal cancer gut microbiota tumor immune surveillance therapeutic response probiotics prebiotics |
| title | Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response |
| title_full | Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response |
| title_fullStr | Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response |
| title_full_unstemmed | Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response |
| title_short | Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response |
| title_sort | gut microbiota in colorectal cancer a review of its influence on tumor immune surveillance and therapeutic response |
| topic | colorectal cancer gut microbiota tumor immune surveillance therapeutic response probiotics prebiotics |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1557959/full |
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