TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Abstract Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is needed. Here, we identified the tumor suppressor pr...

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Main Authors: Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, Hua Xiao, Hugo A Katus, Johann Bauersachs, Oliver J Müller, Joerg Heineke
Format: Article
Language:English
Published: Springer Nature 2019-08-01
Series:EMBO Molecular Medicine
Subjects:
cardiac hypertrophy
cardiomyopathy
heart failure
protein synthesis
translational elongation
Online Access:https://doi.org/10.15252/emmm.201810018
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