Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice
Pasteurella multocida (Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1515977/full |
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| author | Qirong Lu Qirong Lu Luyao Wang Luyao Wang Xueping Jiang Xueping Jiang Wantong Han Wantong Han Pu Guo Pu Guo Yu Liu Yu Liu Shulin Fu Shulin Fu Jianglin Xiong Jianglin Xiong Zhongyuan Wu Zhongyuan Wu Yinsheng Qiu Yinsheng Qiu |
| author_facet | Qirong Lu Qirong Lu Luyao Wang Luyao Wang Xueping Jiang Xueping Jiang Wantong Han Wantong Han Pu Guo Pu Guo Yu Liu Yu Liu Shulin Fu Shulin Fu Jianglin Xiong Jianglin Xiong Zhongyuan Wu Zhongyuan Wu Yinsheng Qiu Yinsheng Qiu |
| author_sort | Qirong Lu |
| collection | DOAJ |
| description | Pasteurella multocida (Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascular protective and anti-inflammatory effects, but its effect on vascular injury caused by Pm infection is not clear. This study focused on the protective effects of GA on Pm-induced vascular inflammatory injury in mice. The results showed that GA intervention significantly improved the survival rate and the changes in haematological and biochemical parameters caused by Pm infection in mice. Haematoxylin and eosin staining revealed that GA delayed the progression of vascular injury, including abnormalities in elastic fibres, local rupture of the vascular intima, and inflammatory cell infiltration in response to Pm infection. The immunohistochemical results showed that after the GA intervention, the vascular inflammatory response in Pm-infected mice was alleviated. These protective effects may be related to the reduced expression of poly (ADP-ribose) polymerase-1, high mobility group box 1, interleukin-1β, and interleukin-18 in vascular tissue by GA. These findings suggest that GA inhibits the activation of inflammation to protect vascular injury in vivo. Hence, GA exhibits therapeutic potential in the treatment of vascular injury. |
| format | Article |
| id | doaj-art-f944cae9968d4d87aa46601c7ad225ef |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-f944cae9968d4d87aa46601c7ad225ef2025-01-09T06:10:05ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15159771515977Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in miceQirong Lu0Qirong Lu1Luyao Wang2Luyao Wang3Xueping Jiang4Xueping Jiang5Wantong Han6Wantong Han7Pu Guo8Pu Guo9Yu Liu10Yu Liu11Shulin Fu12Shulin Fu13Jianglin Xiong14Jianglin Xiong15Zhongyuan Wu16Zhongyuan Wu17Yinsheng Qiu18Yinsheng Qiu19Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaWuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, ChinaPasteurella multocida (Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascular protective and anti-inflammatory effects, but its effect on vascular injury caused by Pm infection is not clear. This study focused on the protective effects of GA on Pm-induced vascular inflammatory injury in mice. The results showed that GA intervention significantly improved the survival rate and the changes in haematological and biochemical parameters caused by Pm infection in mice. Haematoxylin and eosin staining revealed that GA delayed the progression of vascular injury, including abnormalities in elastic fibres, local rupture of the vascular intima, and inflammatory cell infiltration in response to Pm infection. The immunohistochemical results showed that after the GA intervention, the vascular inflammatory response in Pm-infected mice was alleviated. These protective effects may be related to the reduced expression of poly (ADP-ribose) polymerase-1, high mobility group box 1, interleukin-1β, and interleukin-18 in vascular tissue by GA. These findings suggest that GA inhibits the activation of inflammation to protect vascular injury in vivo. Hence, GA exhibits therapeutic potential in the treatment of vascular injury.https://www.frontiersin.org/articles/10.3389/fvets.2024.1515977/full18β-glycyrrhetinic acidinflammatory responsePasteurella multocidaprotective effectsvascular injury |
| spellingShingle | Qirong Lu Qirong Lu Luyao Wang Luyao Wang Xueping Jiang Xueping Jiang Wantong Han Wantong Han Pu Guo Pu Guo Yu Liu Yu Liu Shulin Fu Shulin Fu Jianglin Xiong Jianglin Xiong Zhongyuan Wu Zhongyuan Wu Yinsheng Qiu Yinsheng Qiu Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice Frontiers in Veterinary Science 18β-glycyrrhetinic acid inflammatory response Pasteurella multocida protective effects vascular injury |
| title | Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice |
| title_full | Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice |
| title_fullStr | Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice |
| title_full_unstemmed | Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice |
| title_short | Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice |
| title_sort | protective effects of 18β glycyrrhetinic acid on pasteurella multocida induced vascular inflammatory injury in mice |
| topic | 18β-glycyrrhetinic acid inflammatory response Pasteurella multocida protective effects vascular injury |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1515977/full |
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