Management of Thrombocytopenia in Advanced Liver Disease
Thrombocytopenia (defined as a platelet count <150×109/L) is a well-known complication in patients with liver cirrhosis and has been observed in 76% to 85% of patients. Significant thrombocytopenia (platelet count <50×109/L to 75×109/L) occurs in approximately 13% of patients with cirrhosis. T...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2014/532191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850162744669503488 |
|---|---|
| author | VGR Gangireddy PC Kanneganti S Sridhar S Talla T Coleman |
| author_facet | VGR Gangireddy PC Kanneganti S Sridhar S Talla T Coleman |
| author_sort | VGR Gangireddy |
| collection | DOAJ |
| description | Thrombocytopenia (defined as a platelet count <150×109/L) is a well-known complication in patients with liver cirrhosis and has been observed in 76% to 85% of patients. Significant thrombocytopenia (platelet count <50×109/L to 75×109/L) occurs in approximately 13% of patients with cirrhosis. Thrombocytopenia can negatively impact the care of patients with severe liver disease by potentially interfering with diagnostic and therapeutic procedures. Multiple factors can contribute to the development of thrombocytopenia including splenic platelet sequestration, immunological processes, bone marrow suppression by chronic viral infection, and reduced levels or activity of the hematopoietic growth factor thrombopoietin. The present review focuses on the etiologies and management options for severe thrombocytopenia in the setting of advanced liver disease. |
| format | Article |
| id | doaj-art-f93bc6ebba4a45c8a2acff134aab9cbf |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-f93bc6ebba4a45c8a2acff134aab9cbf2025-08-20T02:22:28ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972014-01-01281055856410.1155/2014/532191Management of Thrombocytopenia in Advanced Liver DiseaseVGR Gangireddy0PC Kanneganti1S Sridhar2S Talla3T Coleman4Georgia Regents University, Augusta, GeorgiaHelena Regional Medical Center, Helena, Arkansas, USAGeorgia Regents University, Augusta, GeorgiaLuzhou Medical College, Luzhou, ChinaArchbold Medical Center, Thomasville, USAThrombocytopenia (defined as a platelet count <150×109/L) is a well-known complication in patients with liver cirrhosis and has been observed in 76% to 85% of patients. Significant thrombocytopenia (platelet count <50×109/L to 75×109/L) occurs in approximately 13% of patients with cirrhosis. Thrombocytopenia can negatively impact the care of patients with severe liver disease by potentially interfering with diagnostic and therapeutic procedures. Multiple factors can contribute to the development of thrombocytopenia including splenic platelet sequestration, immunological processes, bone marrow suppression by chronic viral infection, and reduced levels or activity of the hematopoietic growth factor thrombopoietin. The present review focuses on the etiologies and management options for severe thrombocytopenia in the setting of advanced liver disease.http://dx.doi.org/10.1155/2014/532191 |
| spellingShingle | VGR Gangireddy PC Kanneganti S Sridhar S Talla T Coleman Management of Thrombocytopenia in Advanced Liver Disease Canadian Journal of Gastroenterology and Hepatology |
| title | Management of Thrombocytopenia in Advanced Liver Disease |
| title_full | Management of Thrombocytopenia in Advanced Liver Disease |
| title_fullStr | Management of Thrombocytopenia in Advanced Liver Disease |
| title_full_unstemmed | Management of Thrombocytopenia in Advanced Liver Disease |
| title_short | Management of Thrombocytopenia in Advanced Liver Disease |
| title_sort | management of thrombocytopenia in advanced liver disease |
| url | http://dx.doi.org/10.1155/2014/532191 |
| work_keys_str_mv | AT vgrgangireddy managementofthrombocytopeniainadvancedliverdisease AT pckanneganti managementofthrombocytopeniainadvancedliverdisease AT ssridhar managementofthrombocytopeniainadvancedliverdisease AT stalla managementofthrombocytopeniainadvancedliverdisease AT tcoleman managementofthrombocytopeniainadvancedliverdisease |