Aging and tumors: a dynamic interaction
Abstract Aging is an inevitable physiological process in organisms, and the development of tumors is closely associated with cellular senescence. This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length—a marker of cellular...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-01-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-01808-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585679157067776 |
|---|---|
| author | Yudi Zhang Siqiang Zhu Zhaodong Liu Yonghao Hu Yongjian Zhang Liang Shang Leping Li |
| author_facet | Yudi Zhang Siqiang Zhu Zhaodong Liu Yonghao Hu Yongjian Zhang Liang Shang Leping Li |
| author_sort | Yudi Zhang |
| collection | DOAJ |
| description | Abstract Aging is an inevitable physiological process in organisms, and the development of tumors is closely associated with cellular senescence. This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length—a marker of cellular senescence—and tumor risk. Concurrently, the study explores the expression levels of senescence-associated markers, such as p16, p53, and mTOR, in the context of tumor development. Additionally, the study investigates the impact of tumors on cellular and organismal senescence, including the effects on immune system function and metabolic processes. Ultimately, the discussion explores the potential application of anti-aging strategies in tumor therapy and considers the possibility of utilizing senescence mechanisms as a novel therapeutic approach for tumors. This research provides novel insights into the complex interplay between senescence and tumor development, suggesting potential strategies for future preventative measures and therapeutic interventions. |
| format | Article |
| id | doaj-art-f924e0222db3405ea8b6bfe3b68940ff |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-f924e0222db3405ea8b6bfe3b68940ff2025-01-26T12:39:40ZengSpringerDiscover Oncology2730-60112025-01-0116111610.1007/s12672-025-01808-9Aging and tumors: a dynamic interactionYudi Zhang0Siqiang Zhu1Zhaodong Liu2Yonghao Hu3Yongjian Zhang4Liang Shang5Leping Li6Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital, Shandong UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Aging is an inevitable physiological process in organisms, and the development of tumors is closely associated with cellular senescence. This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length—a marker of cellular senescence—and tumor risk. Concurrently, the study explores the expression levels of senescence-associated markers, such as p16, p53, and mTOR, in the context of tumor development. Additionally, the study investigates the impact of tumors on cellular and organismal senescence, including the effects on immune system function and metabolic processes. Ultimately, the discussion explores the potential application of anti-aging strategies in tumor therapy and considers the possibility of utilizing senescence mechanisms as a novel therapeutic approach for tumors. This research provides novel insights into the complex interplay between senescence and tumor development, suggesting potential strategies for future preventative measures and therapeutic interventions.https://doi.org/10.1007/s12672-025-01808-9AgingTumorCellular senescenceTelomere lengthAnti-aging treatment |
| spellingShingle | Yudi Zhang Siqiang Zhu Zhaodong Liu Yonghao Hu Yongjian Zhang Liang Shang Leping Li Aging and tumors: a dynamic interaction Discover Oncology Aging Tumor Cellular senescence Telomere length Anti-aging treatment |
| title | Aging and tumors: a dynamic interaction |
| title_full | Aging and tumors: a dynamic interaction |
| title_fullStr | Aging and tumors: a dynamic interaction |
| title_full_unstemmed | Aging and tumors: a dynamic interaction |
| title_short | Aging and tumors: a dynamic interaction |
| title_sort | aging and tumors a dynamic interaction |
| topic | Aging Tumor Cellular senescence Telomere length Anti-aging treatment |
| url | https://doi.org/10.1007/s12672-025-01808-9 |
| work_keys_str_mv | AT yudizhang agingandtumorsadynamicinteraction AT siqiangzhu agingandtumorsadynamicinteraction AT zhaodongliu agingandtumorsadynamicinteraction AT yonghaohu agingandtumorsadynamicinteraction AT yongjianzhang agingandtumorsadynamicinteraction AT liangshang agingandtumorsadynamicinteraction AT lepingli agingandtumorsadynamicinteraction |