A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis
The purpose of this systematic review was to assess the consequences of injections of corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) on gait metrics in patients with osteoarthritis (OA). We examined through the Cochrane library, SCOPUS, Web of Science, and PubMed to find...
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Dow University of Health Sciences
2025-03-01
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| author | Hamidreza Aslani Fateme Mirzaee Fatemeh Bahramian Atefeh Aboutorabi Alireza Jalali Bahareh Ahmadinejad |
| author_facet | Hamidreza Aslani Fateme Mirzaee Fatemeh Bahramian Atefeh Aboutorabi Alireza Jalali Bahareh Ahmadinejad |
| author_sort | Hamidreza Aslani |
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The purpose of this systematic review was to assess the consequences of injections of corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) on gait metrics in patients with osteoarthritis (OA). We examined through the Cochrane library, SCOPUS, Web of Science, and PubMed to find pertinent publications that evaluated the effects of CS, HA, and PRP injections on gait parameters in patients with OA of the knee. Utilizing the Physiotherapy Evidence Database (PEDro) scale, quality evaluation was put into practice. A total of 15 publications with 11 randomized control trials based studies describing results for 1160 participants were published. The combined data for velocity showed a significant change with HA injection (SMD: 0.28 95% CI 0.04 to 0.53). In comparison to the control group, the HA injection group's stride length was longer, however the disparity was not statistically significant (SMD: 0.16 95% CI -0.09 to 0.4). No statistically significant differences were observed between the HA and control groups for the other variables. Results demonstrated a significant increase in knee range of motion after CS injection compared to placebo control (MD= 1.70 95% CI -0.03° to 3.37°) and without intervention. There is insufficient data to conclude that PRP and CS have a greater therapeutic advantage than one another in terms of participants' gait. Nonetheless, no intervention is supported by available data, HA is still thought to be more effective than a placebo. To find out how well therapeutic injections affect patients with knee OA's function and gait, more research is needed.
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| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-03-01 |
| publisher | Dow University of Health Sciences |
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| series | Journal of the Dow University of Health Sciences |
| spelling | doaj-art-f90edd7ca4df44bda0b601ac07f00a4b2025-08-20T03:42:28ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802025-03-01409A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee OsteoarthritisHamidreza Aslani0Fateme Mirzaee1Fatemeh Bahramian2Atefeh Aboutorabi3Alireza Jalali4Bahareh Ahmadinejad5Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran. / Shahid Beheshti University of Medical Sciences, Tehran, Iran.Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran.Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran. Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.Health Systems Engineering Research Center, Milad Hospital, Tehran, Iran.Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran. / Health Systems Engineering Research Center, Milad Hospital, Tehran, Iran. The purpose of this systematic review was to assess the consequences of injections of corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) on gait metrics in patients with osteoarthritis (OA). We examined through the Cochrane library, SCOPUS, Web of Science, and PubMed to find pertinent publications that evaluated the effects of CS, HA, and PRP injections on gait parameters in patients with OA of the knee. Utilizing the Physiotherapy Evidence Database (PEDro) scale, quality evaluation was put into practice. A total of 15 publications with 11 randomized control trials based studies describing results for 1160 participants were published. The combined data for velocity showed a significant change with HA injection (SMD: 0.28 95% CI 0.04 to 0.53). In comparison to the control group, the HA injection group's stride length was longer, however the disparity was not statistically significant (SMD: 0.16 95% CI -0.09 to 0.4). No statistically significant differences were observed between the HA and control groups for the other variables. Results demonstrated a significant increase in knee range of motion after CS injection compared to placebo control (MD= 1.70 95% CI -0.03° to 3.37°) and without intervention. There is insufficient data to conclude that PRP and CS have a greater therapeutic advantage than one another in terms of participants' gait. Nonetheless, no intervention is supported by available data, HA is still thought to be more effective than a placebo. To find out how well therapeutic injections affect patients with knee OA's function and gait, more research is needed. https://mail.jduhs.com/index.php/jduhs/article/view/2006CorticosteroidHyaluronic AcidKnee injuryOsteoarthritisPlatelet Rich Plasma |
| spellingShingle | Hamidreza Aslani Fateme Mirzaee Fatemeh Bahramian Atefeh Aboutorabi Alireza Jalali Bahareh Ahmadinejad A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis Journal of the Dow University of Health Sciences Corticosteroid Hyaluronic Acid Knee injury Osteoarthritis Platelet Rich Plasma |
| title | A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis |
| title_full | A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis |
| title_fullStr | A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis |
| title_full_unstemmed | A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis |
| title_short | A Systematic Review of Intra-Articular Hyaluronic Acid, Corticosteroids, and Platelet Rich Plasma Injections on Gait Biomechanics in Knee Osteoarthritis |
| title_sort | systematic review of intra articular hyaluronic acid corticosteroids and platelet rich plasma injections on gait biomechanics in knee osteoarthritis |
| topic | Corticosteroid Hyaluronic Acid Knee injury Osteoarthritis Platelet Rich Plasma |
| url | https://mail.jduhs.com/index.php/jduhs/article/view/2006 |
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