Approaches and applications in transdermal and transpulmonary gene drug delivery
Gene therapy has emerged as a pivotal component in the treatment of diverse genetic and acquired human diseases. However, effective gene delivery remains a formidable challenge to overcome. The presence of degrading enzymes, acidic pH conditions, and the gastrointestinal mucus layer pose significant...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1519557/full |
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| author | Anni Zhang Xuran Zhang Jiahui Chen Xianbao Shi Xijuan Yu Zhonggui He Zhonggui He Jin Sun Jin Sun Mengchi Sun Mengchi Sun Zhijun Liu |
| author_facet | Anni Zhang Xuran Zhang Jiahui Chen Xianbao Shi Xijuan Yu Zhonggui He Zhonggui He Jin Sun Jin Sun Mengchi Sun Mengchi Sun Zhijun Liu |
| author_sort | Anni Zhang |
| collection | DOAJ |
| description | Gene therapy has emerged as a pivotal component in the treatment of diverse genetic and acquired human diseases. However, effective gene delivery remains a formidable challenge to overcome. The presence of degrading enzymes, acidic pH conditions, and the gastrointestinal mucus layer pose significant barriers for genetic therapy, necessitating exploration of alternative therapeutic options. In recent years, transdermal and transpulmonary gene delivery modalities offer promising avenues with multiple advantages, such as non-invasion, avoided liver first-pass effect and improved patient compliance. Considering the rapid development of gene therapeutics via transdermal and transpulmonary administration, here we aim to summarize the nearest advances in transdermal and transpulmonary gene drug delivery. In this review, we firstly elaborate on current delivery carrier in gene therapy. We, further, describe approaches and applications for enhancing transdermal and transpulmonary gene delivery encompassing microneedles, chemical enhancers, physical methods for transdermal administration as well as nebulized formulations, dry powder formulations, and pressurized metered dose formulations for efficient transpulmonary delivery. Last but not least, the opportunities and outlooks of gene therapy through both administrated routes are highlighted. |
| format | Article |
| id | doaj-art-f903a683dfc0411ebb6819ba6b479866 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-f903a683dfc0411ebb6819ba6b4798662025-01-15T11:43:22ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15195571519557Approaches and applications in transdermal and transpulmonary gene drug deliveryAnni Zhang0Xuran Zhang1Jiahui Chen2Xianbao Shi3Xijuan Yu4Zhonggui He5Zhonggui He6Jin Sun7Jin Sun8Mengchi Sun9Mengchi Sun10Zhijun Liu11Department of Ultrasound, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Orthopedics, Fuxin Center Hospital, Fuxin, Liaoning, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, ChinaDepartment of Ultrasound, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaJoint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang, Liaoning, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaJoint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang, Liaoning, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaJoint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang, Liaoning, ChinaDepartment of Ultrasound, Shengjing Hospital, China Medical University, Shenyang, Liaoning, ChinaGene therapy has emerged as a pivotal component in the treatment of diverse genetic and acquired human diseases. However, effective gene delivery remains a formidable challenge to overcome. The presence of degrading enzymes, acidic pH conditions, and the gastrointestinal mucus layer pose significant barriers for genetic therapy, necessitating exploration of alternative therapeutic options. In recent years, transdermal and transpulmonary gene delivery modalities offer promising avenues with multiple advantages, such as non-invasion, avoided liver first-pass effect and improved patient compliance. Considering the rapid development of gene therapeutics via transdermal and transpulmonary administration, here we aim to summarize the nearest advances in transdermal and transpulmonary gene drug delivery. In this review, we firstly elaborate on current delivery carrier in gene therapy. We, further, describe approaches and applications for enhancing transdermal and transpulmonary gene delivery encompassing microneedles, chemical enhancers, physical methods for transdermal administration as well as nebulized formulations, dry powder formulations, and pressurized metered dose formulations for efficient transpulmonary delivery. Last but not least, the opportunities and outlooks of gene therapy through both administrated routes are highlighted.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1519557/fullgene therapytransdermal gene deliverytranspulmonary gene deliverycurrent delivery carrierapproaches and applicationsopportunities and outlooks |
| spellingShingle | Anni Zhang Xuran Zhang Jiahui Chen Xianbao Shi Xijuan Yu Zhonggui He Zhonggui He Jin Sun Jin Sun Mengchi Sun Mengchi Sun Zhijun Liu Approaches and applications in transdermal and transpulmonary gene drug delivery Frontiers in Bioengineering and Biotechnology gene therapy transdermal gene delivery transpulmonary gene delivery current delivery carrier approaches and applications opportunities and outlooks |
| title | Approaches and applications in transdermal and transpulmonary gene drug delivery |
| title_full | Approaches and applications in transdermal and transpulmonary gene drug delivery |
| title_fullStr | Approaches and applications in transdermal and transpulmonary gene drug delivery |
| title_full_unstemmed | Approaches and applications in transdermal and transpulmonary gene drug delivery |
| title_short | Approaches and applications in transdermal and transpulmonary gene drug delivery |
| title_sort | approaches and applications in transdermal and transpulmonary gene drug delivery |
| topic | gene therapy transdermal gene delivery transpulmonary gene delivery current delivery carrier approaches and applications opportunities and outlooks |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1519557/full |
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