Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis)
Аim: to evaluate the state of small intestine permeability by the “double sugar test” in patients with overlap syndrome (autoimmune hepatitis / primary biliary cholangitis (AIH / PBC)).Materials and methods. Prospectively, 56 people were included in the study. Of these, 26 were diagnosed with AIH/PB...
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Gastro LLC
2023-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/734 |
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| author | D. R. Akberova A. Kh. Odintcova D. I. Abdulganieva |
| author_facet | D. R. Akberova A. Kh. Odintcova D. I. Abdulganieva |
| author_sort | D. R. Akberova |
| collection | DOAJ |
| description | Аim: to evaluate the state of small intestine permeability by the “double sugar test” in patients with overlap syndrome (autoimmune hepatitis / primary biliary cholangitis (AIH / PBC)).Materials and methods. Prospectively, 56 people were included in the study. Of these, 26 were diagnosed with AIH/PBC, 30 were in the control group. The diagnosis was made in accordance with the current recommendations. The average age of patients was 49.7 ± 13.8 years, healthy volunteers — 48.6 ± 9.2 years. The determination of the permeability of the small intestine was carried out by a “double sugar test” (the ratio of lactulose/mannitol in urine), using the method of high-performance liquid chromatography — mass spectrometry.Results. In patients with AIH/PBC, an increase in intestinal permeability was found — 0.20 [0.09; 0.30] (p < 0.001) compared with the control group 0.01 [0.01; 0.02]. We divided patients at the stage of liver damage. An increased small intestinal permeability was revealed: hepatitis stage — 0.19 [0.13; 0.30] (p < 0.001), liver cirrhosis stage — 0.18 [0.09; 0.30] (p < 0.05) compared with the control group. In the early stages of disease (1 month from the onset of the disease) had an increased lactulose/mannitol ratio — 0.13 [0.05; 0.26] (p < 0.001) compared to the control group. In the presence of portal hypertension (PH), small intestinal permeability was increased — 0.18 [0.09; 0.30] (p < 0.001) compared with the control group.Conclusions. An increase in small bowel permeability was found in patients with overlapping syndrome. All patients had increased intestinal permeability (regardless of the presence of extrahepatic manifestations). |
| format | Article |
| id | doaj-art-f9033e603cc1428db9875cb93b6efb6b |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-f9033e603cc1428db9875cb93b6efb6b2025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-06-01331515810.22416/1382-4376-2023-33-1-51-58535Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis)D. R. Akberova0A. Kh. Odintcova1D. I. Abdulganieva2Kazan State Medical UniversityRepublic Clinical Hospital of the TatarstanKazan State Medical University; Republic Clinical Hospital of the TatarstanАim: to evaluate the state of small intestine permeability by the “double sugar test” in patients with overlap syndrome (autoimmune hepatitis / primary biliary cholangitis (AIH / PBC)).Materials and methods. Prospectively, 56 people were included in the study. Of these, 26 were diagnosed with AIH/PBC, 30 were in the control group. The diagnosis was made in accordance with the current recommendations. The average age of patients was 49.7 ± 13.8 years, healthy volunteers — 48.6 ± 9.2 years. The determination of the permeability of the small intestine was carried out by a “double sugar test” (the ratio of lactulose/mannitol in urine), using the method of high-performance liquid chromatography — mass spectrometry.Results. In patients with AIH/PBC, an increase in intestinal permeability was found — 0.20 [0.09; 0.30] (p < 0.001) compared with the control group 0.01 [0.01; 0.02]. We divided patients at the stage of liver damage. An increased small intestinal permeability was revealed: hepatitis stage — 0.19 [0.13; 0.30] (p < 0.001), liver cirrhosis stage — 0.18 [0.09; 0.30] (p < 0.05) compared with the control group. In the early stages of disease (1 month from the onset of the disease) had an increased lactulose/mannitol ratio — 0.13 [0.05; 0.26] (p < 0.001) compared to the control group. In the presence of portal hypertension (PH), small intestinal permeability was increased — 0.18 [0.09; 0.30] (p < 0.001) compared with the control group.Conclusions. An increase in small bowel permeability was found in patients with overlapping syndrome. All patients had increased intestinal permeability (regardless of the presence of extrahepatic manifestations).https://www.gastro-j.ru/jour/article/view/734small intestine permeability“double sugar test”overlap syndromeautoimmune hepatitis / primary biliary cholangitis (aih/pbc)extrahepatic manifestations |
| spellingShingle | D. R. Akberova A. Kh. Odintcova D. I. Abdulganieva Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) Российский журнал гастроэнтерологии, гепатологии, колопроктологии small intestine permeability “double sugar test” overlap syndrome autoimmune hepatitis / primary biliary cholangitis (aih/pbc) extrahepatic manifestations |
| title | Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) |
| title_full | Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) |
| title_fullStr | Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) |
| title_full_unstemmed | Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) |
| title_short | Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis) |
| title_sort | evaluation of small intestinal permeability in patients with overlap syndrome autoimmune hepatitis primary biliary cholangitis |
| topic | small intestine permeability “double sugar test” overlap syndrome autoimmune hepatitis / primary biliary cholangitis (aih/pbc) extrahepatic manifestations |
| url | https://www.gastro-j.ru/jour/article/view/734 |
| work_keys_str_mv | AT drakberova evaluationofsmallintestinalpermeabilityinpatientswithoverlapsyndromeautoimmunehepatitisprimarybiliarycholangitis AT akhodintcova evaluationofsmallintestinalpermeabilityinpatientswithoverlapsyndromeautoimmunehepatitisprimarybiliarycholangitis AT diabdulganieva evaluationofsmallintestinalpermeabilityinpatientswithoverlapsyndromeautoimmunehepatitisprimarybiliarycholangitis |